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Category:GO:0004721 ! phosphoprotein phosphatase activity
name: phosphoprotein phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
subset: gosubset_prok
synonym: "phosphoprotein phosphohydrolase activity" EXACT [EC:3.1.3.16]
synonym: "protein phosphatase activity" EXACT []
synonym: "protein phosphatase-1 activity" NARROW [EC:3.1.3.16]
synonym: "protein phosphatase-2A activity" NARROW [EC:3.1.3.16]
synonym: "protein phosphatase-2B activity" NARROW [EC:3.1.3.16]
synonym: "protein phosphatase-2C activity" NARROW [EC:3.1.3.16]
xref: EC:3.1.3.16
xref: MetaCyc:3.1.3.16-RXN
xref: Reactome:REACT_100556 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Canis familiaris"
xref: Reactome:REACT_101161 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Bos taurus"
xref: Reactome:REACT_101258 "Dephosphorylation of phospho-Cdh1, Taeniopygia guttata"
xref: Reactome:REACT_101308 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Mus musculus"
xref: Reactome:REACT_101537 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Drosophila melanogaster"
xref: Reactome:REACT_102055 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Bos taurus"
xref: Reactome:REACT_102521 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Canis familiaris"
xref: Reactome:REACT_103107 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Danio rerio"
xref: Reactome:REACT_105948 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Rattus norvegicus"
xref: Reactome:REACT_106256 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Xenopus tropicalis"
xref: Reactome:REACT_107500 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Taeniopygia guttata"
xref: Reactome:REACT_107570 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Drosophila melanogaster"
xref: Reactome:REACT_108174 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Gallus gallus"
xref: Reactome:REACT_109144 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Drosophila melanogaster"
xref: Reactome:REACT_109225 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Rattus norvegicus"
xref: Reactome:REACT_109310 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Rattus norvegicus"
xref: Reactome:REACT_109345 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Mus musculus"
xref: Reactome:REACT_109732 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Rattus norvegicus"
xref: Reactome:REACT_110596 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Canis familiaris"
xref: Reactome:REACT_111148 "Dephosphorylation of p107 (RBL1) by PP2A, Homo sapiens"
xref: Reactome:REACT_111170 "Dephosphorylation of p130 (RBL2) by PP2A, Homo sapiens"
xref: Reactome:REACT_112020 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Drosophila melanogaster"
xref: Reactome:REACT_112348 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Saccharomyces cerevisiae"
xref: Reactome:REACT_112617 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Saccharomyces cerevisiae"
xref: Reactome:REACT_112795 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Saccharomyces cerevisiae"
xref: Reactome:REACT_112811 "Pp2a mediated localization of Rb protein in chromatin, Xenopus tropicalis"
xref: Reactome:REACT_112981 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Schizosaccharomyces pombe"
xref: Reactome:REACT_113855 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Schizosaccharomyces pombe"
xref: Reactome:REACT_114200 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Schizosaccharomyces pombe"
xref: Reactome:REACT_114550 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Schizosaccharomyces pombe"
xref: Reactome:REACT_115084 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Saccharomyces cerevisiae"
xref: Reactome:REACT_1251 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Homo sapiens"
xref: Reactome:REACT_28268 "Dephosphorylation of phospho-Cdh1, Xenopus tropicalis"
xref: Reactome:REACT_28473 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Canis familiaris"
xref: Reactome:REACT_28474 "Pp2a mediated localization of Rb protein in chromatin, Canis familiaris"
xref: Reactome:REACT_28606 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Gallus gallus"
xref: Reactome:REACT_29645 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Mus musculus"
xref: Reactome:REACT_30225 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Xenopus tropicalis"
xref: Reactome:REACT_33423 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Drosophila melanogaster"
xref: Reactome:REACT_421 "Pp2a mediated localization of Rb protein in chromatin, Homo sapiens"
xref: Reactome:REACT_592 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Homo sapiens"
xref: Reactome:REACT_59811 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Canis familiaris"
xref: Reactome:REACT_6175 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Homo sapiens"
xref: Reactome:REACT_6206 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Homo sapiens"
xref: Reactome:REACT_6255 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Homo sapiens"
xref: Reactome:REACT_6257 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Homo sapiens"
xref: Reactome:REACT_6294 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Homo sapiens"
xref: Reactome:REACT_6910 "Dephosphorylation of phospho-Cdh1, Homo sapiens"
xref: Reactome:REACT_77578 "Dephosphorylation of phospho-Cdh1, Rattus norvegicus"
xref: Reactome:REACT_77594 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Caenorhabditis elegans"
xref: Reactome:REACT_77793 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Danio rerio"
xref: Reactome:REACT_78412 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Mus musculus"
xref: Reactome:REACT_78414 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Saccharomyces cerevisiae"
xref: Reactome:REACT_80229 "Dephosphorylation of phospho-Cdh1, Bos taurus"
xref: Reactome:REACT_80518 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Rattus norvegicus"
xref: Reactome:REACT_81016 "Dephosphorylation of phospho-Cdh1, Sus scrofa"
xref: Reactome:REACT_81195 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Xenopus tropicalis"
xref: Reactome:REACT_81980 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Bos taurus"
xref: Reactome:REACT_83073 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Xenopus tropicalis"
xref: Reactome:REACT_83503 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Danio rerio"
xref: Reactome:REACT_83605 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Dictyostelium discoideum"
xref: Reactome:REACT_83812 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Drosophila melanogaster"
xref: Reactome:REACT_83951 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Bos taurus"
xref: Reactome:REACT_84291 "Pp2a mediated localization of Rb protein in chromatin, Mus musculus"
xref: Reactome:REACT_84834 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Danio rerio"
xref: Reactome:REACT_84882 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Gallus gallus"
xref: Reactome:REACT_86262 "Dephosphorylation of phospho-Cdh1, Schizosaccharomyces pombe"
xref: Reactome:REACT_86293 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Arabidopsis thaliana"
xref: Reactome:REACT_86738 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Xenopus tropicalis"
xref: Reactome:REACT_89601 "Dephosphorylation of phospho-Cdh1, Gallus gallus"
xref: Reactome:REACT_89607 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Xenopus tropicalis"
xref: Reactome:REACT_9062 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Homo sapiens"
xref: Reactome:REACT_90978 "Pp2a mediated localization of Rb protein in chromatin, Taeniopygia guttata"
xref: Reactome:REACT_91918 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Danio rerio"
xref: Reactome:REACT_91996 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Danio rerio"
xref: Reactome:REACT_92154 "Dephosphorylation of phospho-Cdh1, Canis familiaris"
xref: Reactome:REACT_92312 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Bos taurus"
xref: Reactome:REACT_92765 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Oryza sativa"
xref: Reactome:REACT_93167 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Mus musculus"
xref: Reactome:REACT_93324 "Pp2a mediated localization of Rb protein in chromatin, Dictyostelium discoideum"
xref: Reactome:REACT_94004 "Dephosphorylation of phospho-Cdh1, Danio rerio"
xref: Reactome:REACT_95049 "Dephosphorylation of phospho-Cdh1, Mus musculus"
xref: Reactome:REACT_95090 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Mus musculus"
xref: Reactome:REACT_95688 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Drosophila melanogaster"
xref: Reactome:REACT_95930 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Xenopus tropicalis"
xref: Reactome:REACT_95992 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Mus musculus"
xref: Reactome:REACT_97239 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Canis familiaris"
xref: Reactome:REACT_97616 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Taeniopygia guttata"
xref: Reactome:REACT_98140 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Bos taurus"
xref: Reactome:REACT_98946 "Dephosphorylation of phospho-Cdh1, Saccharomyces cerevisiae"
xref: Reactome:REACT_98958 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Rattus norvegicus"
xref: Reactome:REACT_98967 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Schizosaccharomyces pombe"
xref: Reactome:REACT_99508 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Danio rerio"
xref: Reactome:REACT_99511 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Taeniopygia guttata"
xref: Reactome:REACT_99512 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Rattus norvegicus"
is_a: GO:0016791 ! phosphatase activity
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