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Category:GO:0004517 ! nitric-oxide synthase activity
name: nitric-oxide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39]
subset: gosubset_prok
synonym: "endothelium-derived relaxation factor-forming enzyme activity" RELATED [EC:1.14.13.39]
synonym: "endothelium-derived relaxing factor synthase activity" RELATED [EC:1.14.13.39]
synonym: "L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity" EXACT [EC:1.14.13.39]
synonym: "NADPH-diaphorase activity" EXACT [EC:1.14.13.39]
synonym: "nitric oxide synthase activity" EXACT []
synonym: "nitric oxide synthetase activity" EXACT [EC:1.14.13.39]
synonym: "nitric-oxide synthetase activity" EXACT [EC:1.14.13.39]
synonym: "NO synthase activity" EXACT [EC:1.14.13.39]
xref: EC:1.14.13.39
xref: MetaCyc:NITRIC-OXIDE-SYNTHASE-RXN
xref: Reactome:REACT_100132 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO), Rattus norvegicus"
xref: Reactome:REACT_105423 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO), Canis familiaris"
xref: Reactome:REACT_113518 "NO biosynthesis, Taeniopygia guttata"
xref: Reactome:REACT_12443 "NO biosynthesis, Homo sapiens"
xref: Reactome:REACT_23872 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO), Homo sapiens"
xref: Reactome:REACT_29232 "NO biosynthesis, Rattus norvegicus"
xref: Reactome:REACT_30996 "NO biosynthesis, Sus scrofa"
xref: Reactome:REACT_77300 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO), Xenopus tropicalis"
xref: Reactome:REACT_77934 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO), Gallus gallus"
xref: Reactome:REACT_80256 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO), Bos taurus"
xref: Reactome:REACT_84552 "NO biosynthesis, Mus musculus"
xref: Reactome:REACT_85890 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO), Mus musculus"
xref: Reactome:REACT_86754 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO), Taeniopygia guttata"
xref: Reactome:REACT_88372 "NO biosynthesis, Canis familiaris"
xref: Reactome:REACT_90393 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO), Danio rerio"
xref: Reactome:REACT_91384 "NO biosynthesis, Bos taurus"
xref: Reactome:REACT_94267 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO), Sus scrofa"
xref: Reactome:REACT_99750 "NO biosynthesis, Xenopus tropicalis"
xref: RHEA:24668
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
AmiGO
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