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Category:GO:0004508 ! steroid 17-alpha-monooxygenase activity
name: steroid 17-alpha-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O." [EC:1.14.99.9]
synonym: "17alpha-hydroxylase-C17,20 lyase activity" EXACT [EC:1.14.99.9]
synonym: "cytochrome P-450 (P-45017alpha,lyase)" RELATED [EC:1.14.99.9]
synonym: "cytochrome P450 CYP17" NARROW []
synonym: "cytochrome p450 XVIIA1 activity" NARROW [EC:1.14.99.9]
synonym: "cytochrome P45017alpha" RELATED [EC:1.14.99.9]
synonym: "steroid 17-alpha-hydroxylase activity" EXACT []
synonym: "steroid 17-alpha-hydroxylase-C17-20 lyase activity" EXACT []
synonym: "steroid 17-alpha-hydroxylase/17,20 lyase activity" EXACT [EC:1.14.99.9]
synonym: "steroid 17alpha-hydroxylase activity" EXACT [EC:1.14.99.9]
synonym: "steroid 17alpha-monooxygenase activity" EXACT [EC:1.14.99.9]
synonym: "steroid 17alphahydroxylase/17,20 lyase activity" EXACT [EC:1.14.99.9]
synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)" EXACT [EC:1.14.99.9]
xref: EC:1.14.99.9
xref: MetaCyc:STEROID-17-ALPHA-MONOOXYGENASE-RXN
xref: Reactome:REACT_10013 "Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione, Homo sapiens"
xref: Reactome:REACT_10026 "Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA, Homo sapiens"
xref: Reactome:REACT_100552 "Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone, Mus musculus"
xref: Reactome:REACT_10116 "Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone, Homo sapiens"
xref: Reactome:REACT_101338 "Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA, Danio rerio"
xref: Reactome:REACT_102153 "Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione, Taeniopygia guttata"
xref: Reactome:REACT_103760 "Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA, Bos taurus"
xref: Reactome:REACT_112434 "Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione, Gallus gallus"
xref: Reactome:REACT_113135 "Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA, Gallus gallus"
xref: Reactome:REACT_113443 "Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone, Gallus gallus"
xref: Reactome:REACT_114963 "Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone, Gallus gallus"
xref: Reactome:REACT_28596 "Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone, Rattus norvegicus"
xref: Reactome:REACT_29409 "Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone, Danio rerio"
xref: Reactome:REACT_33249 "Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione, Sus scrofa"
xref: Reactome:REACT_33293 "Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA, Xenopus tropicalis"
xref: Reactome:REACT_34716 "Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA, Taeniopygia guttata"
xref: Reactome:REACT_78029 "Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione, Canis familiaris"
xref: Reactome:REACT_78073 "Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione, Danio rerio"
xref: Reactome:REACT_78525 "Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone, Danio rerio"
xref: Reactome:REACT_80011 "Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione, Mus musculus"
xref: Reactome:REACT_80170 "Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone, Bos taurus"
xref: Reactome:REACT_80368 "Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone, Xenopus tropicalis"
xref: Reactome:REACT_80594 "Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA, Canis familiaris"
xref: Reactome:REACT_81577 "Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone, Rattus norvegicus"
xref: Reactome:REACT_82145 "Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone, Sus scrofa"
xref: Reactome:REACT_82553 "Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA, Mus musculus"
xref: Reactome:REACT_82875 "Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA, Sus scrofa"
xref: Reactome:REACT_83833 "Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone, Mus musculus"
xref: Reactome:REACT_85094 "Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione, Xenopus tropicalis"
xref: Reactome:REACT_85131 "Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone, Taeniopygia guttata"
xref: Reactome:REACT_85525 "Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone, Sus scrofa"
xref: Reactome:REACT_85752 "Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone, Canis familiaris"
xref: Reactome:REACT_88873 "Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone, Canis familiaris"
xref: Reactome:REACT_90551 "Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA, Rattus norvegicus"
xref: Reactome:REACT_90696 "Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione, Bos taurus"
xref: Reactome:REACT_95449 "Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone, Taeniopygia guttata"
xref: Reactome:REACT_95861 "Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone, Xenopus tropicalis"
xref: Reactome:REACT_98312 "Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione, Rattus norvegicus"
xref: Reactome:REACT_98314 "Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone, Bos taurus"
xref: Reactome:REACT_9993 "Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone, Homo sapiens"
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
AmiGO
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