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Category:GO:0004498 ! calcidiol 1-monooxygenase activity
name: calcidiol 1-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+)." [EC:1.14.13.13, RHEA:20576]
synonym: "1-hydroxylase-25-hydroxyvitamin D3 activity" RELATED [EC:1.14.13.13]
synonym: "25-hydroxy D3-1alpha-hydroxylase activity" EXACT [EC:1.14.13.13]
synonym: "25-hydroxy vitamin D3 1-alpha-hydroxylase activity" EXACT []
synonym: "25-hydroxycholecalciferol 1-hydroxylase activity" EXACT []
synonym: "25-hydroxycholecalciferol 1-monooxygenase activity" EXACT [EC:1.14.13.13]
synonym: "25-hydroxycholecalciferol 1alpha-hydroxylase activity" EXACT [EC:1.14.13.13]
synonym: "25-hydroxycholecalciferol-1-hydroxylase activity" EXACT [EC:1.14.13.13]
synonym: "25-hydroxyvitamin D-1 alpha hydroxylase activity" EXACT [EC:1.14.13.13]
synonym: "25-hydroxyvitamin D3 1alpha-hydroxylase activity" EXACT [EC:1.14.13.13]
synonym: "25-OHD-1 alpha-hydroxylase activity" EXACT [EC:1.14.13.13]
synonym: "calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)" EXACT [EC:1.14.13.13]
synonym: "cytochrome P450 CYP27B" NARROW []
xref: EC:1.14.13.13
xref: KEGG:R03610
xref: MetaCyc:CALCIDIOL-1-MONOOXYGENASE-RXN
xref: Reactome:REACT_102929 "Further hydroxylation of calcidiol in kidney to form calcitriol, Danio rerio"
xref: Reactome:REACT_106826 "Further hydroxylation of calcidiol in kidney to form calcitriol, Drosophila melanogaster"
xref: Reactome:REACT_110331 "Further hydroxylation of calcidiol in kidney to form calcitriol, Canis familiaris"
xref: Reactome:REACT_13628 "Further hydroxylation of calcidiol in kidney to form calcitriol, Homo sapiens"
xref: Reactome:REACT_83168 "Further hydroxylation of calcidiol in kidney to form calcitriol, Xenopus tropicalis"
xref: Reactome:REACT_84663 "Further hydroxylation of calcidiol in kidney to form calcitriol, Bos taurus"
xref: Reactome:REACT_93300 "Further hydroxylation of calcidiol in kidney to form calcitriol, Mus musculus"
xref: RHEA:20576
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
AmiGO
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