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Category:GO:0004356 ! glutamate-ammonia ligase activity
name: glutamate-ammonia ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + ATP + NH(4)(+) = L-glutamine + ADP + 2 H(+) + phosphate." [EC:6.3.1.2, RHEA:16172]
subset: gosubset_prok
synonym: "glutamine synthetase activity" EXACT []
synonym: "glutamylhydroxamic synthetase activity" EXACT [EC:6.3.1.2]
synonym: "L-glutamate:ammonia ligase (ADP-forming)" EXACT [EC:6.3.1.2]
synonym: "L-glutamine synthetase activity" EXACT [EC:6.3.1.2]
xref: EC:6.3.1.2
xref: KEGG:R00253
xref: MetaCyc:GLUTAMINESYN-RXN
xref: Reactome:REACT_104006 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Danio rerio"
xref: Reactome:REACT_104940 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Drosophila melanogaster"
xref: Reactome:REACT_110265 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Gallus gallus"
xref: Reactome:REACT_112105 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Oryza sativa"
xref: Reactome:REACT_115035 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Arabidopsis thaliana"
xref: Reactome:REACT_1171 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Homo sapiens"
xref: Reactome:REACT_28913 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Sus scrofa"
xref: Reactome:REACT_33705 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Canis familiaris"
xref: Reactome:REACT_34384 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Saccharomyces cerevisiae"
xref: Reactome:REACT_39662 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Caenorhabditis elegans"
xref: Reactome:REACT_77424 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Bos taurus"
xref: Reactome:REACT_77661 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Schizosaccharomyces pombe"
xref: Reactome:REACT_86685 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Xenopus tropicalis"
xref: Reactome:REACT_90402 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Mus musculus"
xref: Reactome:REACT_90408 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Taeniopygia guttata"
xref: Reactome:REACT_92620 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Rattus norvegicus"
xref: RHEA:16172
is_a: GO:0016211 ! ammonia ligase activity
AmiGO
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