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Category:GO:0004353 ! glutamate dehydrogenase (NAD(P)+) activity
name: glutamate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+." [EC:1.4.1.3]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
subset: gosubset_prok
synonym: "glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)" RELATED []
synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" RELATED []
synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.3]
synonym: "L-glutamate:NAD(P)+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.3]
xref: EC:1.4.1.3
xref: MetaCyc:GLUTAMATE-DEHYDROGENASE-NADP+-RXN
xref: MetaCyc:GLUTAMATE-SYN2-PWY
xref: Reactome:REACT_100655 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1], Drosophila melanogaster"
xref: Reactome:REACT_100656 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1], Gallus gallus"
xref: Reactome:REACT_104090 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1], Taeniopygia guttata"
xref: Reactome:REACT_105114 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1], Dictyostelium discoideum"
xref: Reactome:REACT_106901 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1], Gallus gallus"
xref: Reactome:REACT_109912 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1], Danio rerio"
xref: Reactome:REACT_112437 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1], Canis familiaris"
xref: Reactome:REACT_112733 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1], Staphylococcus aureus N315"
xref: Reactome:REACT_113249 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1], Staphylococcus aureus N315"
xref: Reactome:REACT_114470 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1], Canis familiaris"
xref: Reactome:REACT_1896 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1], Homo sapiens"
xref: Reactome:REACT_28386 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1], Drosophila melanogaster"
xref: Reactome:REACT_710 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1], Homo sapiens"
xref: Reactome:REACT_78365 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1], Mus musculus"
xref: Reactome:REACT_82868 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1], Xenopus tropicalis"
xref: Reactome:REACT_83965 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1], Dictyostelium discoideum"
xref: Reactome:REACT_90113 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1], Taeniopygia guttata"
xref: Reactome:REACT_93428 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1], Caenorhabditis elegans"
xref: Reactome:REACT_94386 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1], Caenorhabditis elegans"
xref: Reactome:REACT_95081 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1], Mus musculus"
xref: Reactome:REACT_95259 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1], Danio rerio"
xref: Reactome:REACT_96021 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1], Xenopus tropicalis"
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
AmiGO
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