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Category:GO:0004348 ! glucosylceramidase activity
name: glucosylceramidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine." [EC:3.2.1.45]
subset: gosubset_prok
synonym: "acid beta-glucosidase activity" EXACT [EC:3.2.1.45]
synonym: "beta-D-glucocerebrosidase activity" EXACT [EC:3.2.1.45]
synonym: "beta-glucocerebrosidase activity" EXACT [EC:3.2.1.45]
synonym: "beta-glucosylceramidase activity" EXACT [EC:3.2.1.45]
synonym: "ceramide glucosidase activity" EXACT [EC:3.2.1.45]
synonym: "D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [EC:3.2.1.45]
synonym: "GlcCer-beta-glucosidase activity" EXACT [EC:3.2.1.45]
synonym: "glucocerebrosidase activity" EXACT [EC:3.2.1.45]
synonym: "glucosphingosine glucosylhydrolase activity" EXACT [EC:3.2.1.45]
synonym: "glucosylcerebrosidase activity" EXACT [EC:3.2.1.45]
synonym: "glucosylsphingosine beta-D-glucosidase activity" EXACT [EC:3.2.1.45]
synonym: "glucosylsphingosine beta-glucosidase activity" EXACT [EC:3.2.1.45]
synonym: "psychosine hydrolase activity" EXACT [EC:3.2.1.45]
xref: EC:3.2.1.45
xref: MetaCyc:GLUCOSYLCERAMIDASE-RXN
xref: Reactome:REACT_115656 "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide, Homo sapiens"
xref: Reactome:REACT_115663 "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol), Homo sapiens"
xref: Reactome:REACT_115724 "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane), Homo sapiens"
xref: RHEA:13272
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
AmiGO
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See Also
Glucocerebrosidase mutations and multiple system atrophy [1]
Enzyme replacement therapy for Gaucher disease. [2]
References
See Help:References for how to manage references in GONUTS.
- ↑ Segarane B et al. (2009) Glucocerebrosidase mutations in 108 neuropathologically confirmed cases of multiple system atrophy. Neurology 72: 1185-6 PubMed GONUTS page
- ↑ Charrow J (2009) Enzyme replacement therapy for Gaucher disease. Expert Opin Biol Ther 9: 121-31 PubMed GONUTS page
