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Category:GO:0004345 ! glucose-6-phosphate dehydrogenase activity
name: glucose-6-phosphate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+." [EC:1.1.1.49]
subset: gosubset_prok
synonym: "6-phosphoglucose dehydrogenas" RELATED []
synonym: "6-phosphoglucose dehydrogenase activity" EXACT []
synonym: "D-glucose 6-phosphate dehydrogenase activity" EXACT []
synonym: "D-glucose-6-phosphate:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.49]
synonym: "Entner-doudoroff enzyme" RELATED [EC:1.1.1.49]
synonym: "G6PD activity" EXACT [EC:1.1.1.49]
synonym: "G6PDH" EXACT []
synonym: "GDH" RELATED []
synonym: "glucose 6-phosphate dehydrogenase (NADP) activity" EXACT []
synonym: "glucose-6-phosphate 1-dehydrogenase activity" EXACT []
synonym: "NADP-dependent glucose 6-phosphate dehydrogenase activity" EXACT []
synonym: "NADP-glucose-6-phosphate dehydrogenase activity" EXACT []
synonym: "Zwischenferment" RELATED []
synonym: "zwischenferment" RELATED [EC:1.1.1.49]
xref: EC:1.1.1.49
xref: MetaCyc:GLU6PDEHYDROG-RXN
xref: Reactome:REACT_102558 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Mus musculus"
xref: Reactome:REACT_104275 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Rattus norvegicus"
xref: Reactome:REACT_112685 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Plasmodium falciparum"
xref: Reactome:REACT_114196 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Xenopus tropicalis"
xref: Reactome:REACT_114740 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Dictyostelium discoideum"
xref: Reactome:REACT_1868 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Homo sapiens"
xref: Reactome:REACT_28663 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Staphylococcus aureus N315"
xref: Reactome:REACT_29982 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Mycobacterium tuberculosis"
xref: Reactome:REACT_31126 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Escherichia coli"
xref: Reactome:REACT_33226 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Danio rerio"
xref: Reactome:REACT_33546 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Arabidopsis thaliana"
xref: Reactome:REACT_34758 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Oryza sativa"
xref: Reactome:REACT_80140 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Canis familiaris"
xref: Reactome:REACT_83159 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Drosophila melanogaster"
xref: Reactome:REACT_84676 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Saccharomyces cerevisiae"
xref: Reactome:REACT_87680 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Bos taurus"
xref: Reactome:REACT_89131 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Schizosaccharomyces pombe"
xref: Reactome:REACT_90405 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Caenorhabditis elegans"
xref: RHEA:15844
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
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