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Category:GO:0004312 ! fatty acid synthase activity
name: fatty acid synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+." [EC:2.3.1.85]
subset: gosubset_prok
synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)" EXACT [EC:2.3.1.85]
synonym: "fatty-acid synthase activity" EXACT []
xref: EC:2.3.1.85
xref: MetaCyc:FATTY-ACID-SYNTHASE-RXN
xref: Reactome:REACT_112198 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Mycobacterium tuberculosis"
xref: Reactome:REACT_113128 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Dictyostelium discoideum"
xref: Reactome:REACT_1497 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Homo sapiens"
xref: Reactome:REACT_28371 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Danio rerio"
xref: Reactome:REACT_78047 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Xenopus tropicalis"
xref: Reactome:REACT_81687 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Mus musculus"
xref: Reactome:REACT_81811 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Drosophila melanogaster"
xref: Reactome:REACT_83657 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Gallus gallus"
xref: Reactome:REACT_83733 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Canis familiaris"
xref: Reactome:REACT_91445 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Taeniopygia guttata"
xref: Reactome:REACT_96308 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Bos taurus"
xref: Reactome:REACT_97636 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Caenorhabditis elegans"
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups
AmiGO
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