Category:GO:0004222 ! metalloendopeptidase activity

name: metalloendopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
subset: gosubset_prok
synonym: "metalloendoprotease activity" EXACT [GOC:mah]
synonym: "metalloendoproteinase activity" EXACT [GOC:mah]
xref: EC:3.4.24
xref: Reactome:REACT_100500 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Mus musculus"
xref: Reactome:REACT_102187 "Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Bos taurus"
xref: Reactome:REACT_102738 "Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Rattus norvegicus"
xref: Reactome:REACT_104692 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Gallus gallus"
xref: Reactome:REACT_104704 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Canis familiaris"
xref: Reactome:REACT_105137 "Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Taeniopygia guttata"
xref: Reactome:REACT_105311 "Pro-EGF is cleaved to form mature EGF, Rattus norvegicus"
xref: Reactome:REACT_109473 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Rattus norvegicus"
xref: Reactome:REACT_11089 "BoNT Light Chain Type E cleaves SNAP-25, Homo sapiens"
xref: Reactome:REACT_111084 "ADAM17 cleavage of Ghr, Mus musculus"
xref: Reactome:REACT_111197 "Metalloprotease cleavage of GHR, Homo sapiens"
xref: Reactome:REACT_11130 "BoNT Light Chain Type C1 cleaves SNAP-25, Homo sapiens"
xref: Reactome:REACT_11146 "BoNT Light Chain Type A cleaves SNAP-25, Homo sapiens"
xref: Reactome:REACT_11158 "BoNT Light Chain Type F cleaves VAMP, Homo sapiens"
xref: Reactome:REACT_11165 "BoNT Light Chain Type B cleaves VAMP-2, Homo sapiens"
xref: Reactome:REACT_11179 "BoNT Light Chain Type D cleaves VAMP, Homo sapiens"
xref: Reactome:REACT_11195 "BoNT Light Chain Type C1 cleaves Syntaxin, Homo sapiens"
xref: Reactome:REACT_115618 "Cleavage of P-ERBB4jmA isoforms by ADAM17, Homo sapiens"
xref: Reactome:REACT_115992 "Cleavage of P-ERBB4jmA isoforms by Adam17, Homo sapiens"
xref: Reactome:REACT_13407 "Conversion of pro-apoA-I to apoA-I, Homo sapiens"
xref: Reactome:REACT_15304 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Homo sapiens"
xref: Reactome:REACT_15447 "Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Homo sapiens"
xref: Reactome:REACT_15475 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Homo sapiens"
xref: Reactome:REACT_28155 "Pro-EGF is cleaved to form mature EGF, Taeniopygia guttata"
xref: Reactome:REACT_28465 "Pro-EGF is cleaved to form mature EGF, Xenopus tropicalis"
xref: Reactome:REACT_30819 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Taeniopygia guttata"
xref: Reactome:REACT_30876 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Bos taurus"
xref: Reactome:REACT_31204 "Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Mus musculus"
xref: Reactome:REACT_31767 "Conversion of pro-apoA-I to apoA-I, Danio rerio"
xref: Reactome:REACT_32065 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Bos taurus"
xref: Reactome:REACT_33032 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Canis familiaris"
xref: Reactome:REACT_33649 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Gallus gallus"
xref: Reactome:REACT_34637 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Danio rerio"
xref: Reactome:REACT_46117 "Pro-EGF is cleaved to form mature EGF, Gallus gallus"
xref: Reactome:REACT_48941 "Conversion of pro-apoA-I to apoA-I, Bos taurus"
xref: Reactome:REACT_79685 "Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Canis familiaris"
xref: Reactome:REACT_81221 "Pro-EGF is cleaved to form mature EGF, Canis familiaris"
xref: Reactome:REACT_83047 "Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Xenopus tropicalis"
xref: Reactome:REACT_84535 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Danio rerio"
xref: Reactome:REACT_85568 "Pro-EGF is cleaved to form mature EGF, Danio rerio"
xref: Reactome:REACT_85944 "Conversion of pro-apoA-I to apoA-I, Xenopus tropicalis"
xref: Reactome:REACT_87955 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Sus scrofa"
xref: Reactome:REACT_89938 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Xenopus tropicalis"
xref: Reactome:REACT_9030 "Mouse pro-EGF is cleaved by ADAM sheddases, Mus musculus"
xref: Reactome:REACT_90847 "Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Sus scrofa"
xref: Reactome:REACT_91391 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Mus musculus"
xref: Reactome:REACT_93439 "Conversion of pro-apoA-I to apoA-I, Mus musculus"
xref: Reactome:REACT_9423 "Pro-EGF is cleaved to form mature EGF, Homo sapiens"
xref: Reactome:REACT_96741 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Taeniopygia guttata"
xref: Reactome:REACT_97379 "Conversion of pro-apoA-I to apoA-I, Sus scrofa"
xref: Reactome:REACT_97836 "Conversion of pro-apoA-I to apoA-I, Canis familiaris"
xref: Reactome:REACT_98257 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Rattus norvegicus"
xref: Reactome:REACT_98581 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Sus scrofa"
is_a: GO:0004175 ! endopeptidase activity
is_a: GO:0008237 ! metallopeptidase activity

AmiGO

Pages in category "GO:0004222 ! metalloendopeptidase activity"

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