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Category:GO:0004190 ! aspartic-type endopeptidase activity
name: aspartic-type endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
subset: gosubset_prok
synonym: "aspartate protease activity" EXACT [GOC:mah, GOC:vw]
synonym: "aspartic endopeptidase activity" EXACT []
synonym: "aspartic protease activity" EXACT []
synonym: "aspartyl protease activity" EXACT []
synonym: "carboxyl protease activity" EXACT []
xref: EC:3.4.23
xref: Reactome:REACT_100150 "NEXT1 is cleaved to produce NICD1, Gallus gallus"
xref: Reactome:REACT_100746 "NEXT2 is cleaved to produce NICD2, Rattus norvegicus"
xref: Reactome:REACT_102828 "NEXT1 is cleaved to produce NICD1, Xenopus tropicalis"
xref: Reactome:REACT_103663 "NEXT4 is cleaved to produce NICD4, Bos taurus"
xref: Reactome:REACT_103855 "NEXT2 is cleaved to produce NICD2, Drosophila melanogaster"
xref: Reactome:REACT_106913 "NEXT4 is cleaved to produce NICD4, Mus musculus"
xref: Reactome:REACT_108687 "NEXT3 is cleaved to produce NICD3, Danio rerio"
xref: Reactome:REACT_108752 "NEXT4 is cleaved to produce NICD4, Canis familiaris"
xref: Reactome:REACT_110055 "NEXT2 is cleaved to produce NICD2, Xenopus tropicalis"
xref: Reactome:REACT_114839 "NEXT4 is cleaved to produce NICD4, Xenopus tropicalis"
xref: Reactome:REACT_114927 "NEXT3 is cleaved to produce NICD3, Drosophila melanogaster"
xref: Reactome:REACT_1306 "NEXT2 is cleaved to produce NICD2, Homo sapiens"
xref: Reactome:REACT_1784 "NEXT1 is cleaved to produce NICD1, Homo sapiens"
xref: Reactome:REACT_1803 "NEXT3 is cleaved to produce NICD3, Homo sapiens"
xref: Reactome:REACT_28604 "NEXT1 is cleaved to produce NICD1, Danio rerio"
xref: Reactome:REACT_29012 "NEXT4 is cleaved to produce NICD4, Sus scrofa"
xref: Reactome:REACT_29591 "NEXT4 is cleaved to produce NICD4, Rattus norvegicus"
xref: Reactome:REACT_30254 "NEXT3 is cleaved to produce NICD3, Bos taurus"
xref: Reactome:REACT_32331 "NEXT3 is cleaved to produce NICD3, Xenopus tropicalis"
xref: Reactome:REACT_34376 "NEXT1 is cleaved to produce NICD1, Drosophila melanogaster"
xref: Reactome:REACT_77061 "NEXT1 is cleaved to produce NICD1, Rattus norvegicus"
xref: Reactome:REACT_78562 "NEXT2 is cleaved to produce NICD2, Canis familiaris"
xref: Reactome:REACT_78689 "NEXT3 is cleaved to produce NICD3, Mus musculus"
xref: Reactome:REACT_80559 "NEXT2 is cleaved to produce NICD2, Mus musculus"
xref: Reactome:REACT_82242 "NEXT2 is cleaved to produce NICD2, Bos taurus"
xref: Reactome:REACT_82441 "NEXT1 is cleaved to produce NICD1, Taeniopygia guttata"
xref: Reactome:REACT_89773 "NEXT1 is cleaved to produce NICD1, Bos taurus"
xref: Reactome:REACT_89990 "NEXT3 is cleaved to produce NICD3, Canis familiaris"
xref: Reactome:REACT_93093 "NEXT2 is cleaved to produce NICD2, Gallus gallus"
xref: Reactome:REACT_93980 "NEXT2 is cleaved to produce NICD2, Sus scrofa"
xref: Reactome:REACT_95514 "NEXT1 is cleaved to produce NICD1, Canis familiaris"
xref: Reactome:REACT_96133 "NEXT2 is cleaved to produce NICD2, Danio rerio"
xref: Reactome:REACT_96159 "NEXT1 is cleaved to produce NICD1, Mus musculus"
xref: Reactome:REACT_965 "NEXT4 is cleaved to produce NICD4, Homo sapiens"
xref: Reactome:REACT_97765 "NEXT3 is cleaved to produce NICD3, Rattus norvegicus"
is_a: GO:0004175 ! endopeptidase activity
is_a: GO:0070001 ! aspartic-type peptidase activity
AmiGO
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