Category:GO:0004000 ! adenosine deaminase activity

id: GO:0004000

name: adenosine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
subset: gosubset_prok
synonym: "adenosine aminohydrolase activity" EXACT [EC:3.5.4.4]
synonym: "adenosine deaminase reaction" EXACT []
xref: EC:3.5.4.4
xref: MetaCyc:ADENODEAMIN-RXN
xref: Reactome:REACT_107117 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Rattus norvegicus"
xref: Reactome:REACT_107659 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Gallus gallus"
xref: Reactome:REACT_113447 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Plasmodium falciparum"
xref: Reactome:REACT_114346 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Mycobacterium tuberculosis"
xref: Reactome:REACT_2135 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Homo sapiens"
xref: Reactome:REACT_32268 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Bos taurus"
xref: Reactome:REACT_34635 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Mus musculus"
xref: Reactome:REACT_84913 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Canis familiaris"
xref: Reactome:REACT_92015 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Caenorhabditis elegans"
xref: Reactome:REACT_93814 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Danio rerio"
xref: Reactome:REACT_98610 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Escherichia coli"
xref: RHEA:24411
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

AmiGO

Last version checked date: 06:02:2012 15:08 saved-by: rfoulger auto-generated-by: OBO-Edit 2.1

Last updated date: 28:10:2011 16:35 saved-by: gwg auto-generated-by: OBO-Edit 2.0

Gene Ontology Home
The contents of this box are automatically generated. You can help by adding information to the "Notes"

Usage Notes

Adenosine deaminase is an enzyme involved in purine metabolism, which irreversibly deaminates both adenosine and deoxyadenosine to inosine and deoxyinosine. The optimal pH for this enzyme is around 7.5-8, but activity is irreversibly lost when pH is lower than 2.7 or higher than 9.5. Adenosine deaminase is sensitive to heavy metals, such as Ag+, Cu2+, and Cr3+, and reacts with them irreversibly (Koch, 1958). ^[1]

Complications in purine metabolism often result in various disorders in humans. Deficiencies amounts of adenosine deaminase result in diseases such as severe combined immunodeficiency disorder (SCID) and lymphopenia.

See Also

Adenosine Deaminase in SCID^[2]

Adenosine Deaminase and Lymphocyte Development ^[3]

Enzyme Therapy for Adenosine Deaminase Deficiency ^[4]

Gene Therapy for ADA-Deficient SCID ^[5]

References

See Help:References for how to manage references in GONUTS.

1. ↑ KOCH AL & VALLEE G (1959) The properties of adenosine deaminase and adenosine nucleoside phosphorylase in extracts of Escherichia coli. J Biol Chem 234: 1213-8 PubMed GONUTS page
2. ↑ Apasov SG et al. (2001) Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling. J Clin Invest 108: 131-41 PubMed GONUTS page
3. ↑ Aldrich MB et al. (2000) The importance of adenosine deaminase for lymphocyte development and function. Biochem Biophys Res Commun 272: 311-5 PubMed GONUTS page
4. ↑ Blackburn MR et al. (2000) The use of enzyme therapy to regulate the metabolic and phenotypic consequences of adenosine deaminase deficiency in mice. Differential impact on pulmonary and immunologic abnormalities. J Biol Chem 275: 32114-21 PubMed GONUTS page
5. ↑ Aiuti A (2004) Gene therapy for adenosine-deaminase-deficient severe combined immunodeficiency. Best Pract Res Clin Haematol 17: 505-16 PubMed GONUTS page

External links

• Wikipedia: adenosine deaminase
• EcoliWiki: adenosine deaminase