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Category:GO:0003854 ! 3-beta-hydroxy-delta5-steroid dehydrogenase activity
name: 3-beta-hydroxy-delta5-steroid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+)." [EC:1.1.1.145]
subset: gosubset_prok
synonym: "3-beta-hydroxy-5-ene steroid dehydrogenase activity" EXACT [EC:1.1.1.145]
synonym: "3-beta-hydroxy-D5-steroid dehydrogenase activity" EXACT []
synonym: "3beta-HSDH" RELATED [EC:1.1.1.145]
synonym: "3beta-hydroxy steroid dehydrogenase/isomerase activity" EXACT [EC:1.1.1.145]
synonym: "3beta-hydroxy-5-ene steroid dehydrogenase activity" EXACT [EC:1.1.1.145]
synonym: "3beta-hydroxy-5-ene-steroid dehydrogenase activity" EXACT [EC:1.1.1.145]
synonym: "3beta-hydroxy-5-ene-steroid oxidoreductase activity" EXACT [EC:1.1.1.145]
synonym: "3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase activity" EXACT [EC:1.1.1.145]
synonym: "3beta-hydroxy-delta5-C27-steroid oxidoreductase" BROAD [EC:1.1.1.145]
synonym: "3beta-hydroxy-delta5-steroid dehydrogenase activity" EXACT [EC:1.1.1.145]
synonym: "3beta-hydroxy-delta5-steroid:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.145]
synonym: "5-ene-3-beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.145]
synonym: "delta5-3beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.145]
synonym: "progesterone reductase activity" BROAD [EC:1.1.1.145]
synonym: "steroid-delta5-3beta-ol dehydrogenase activity" EXACT [EC:1.1.1.145]
xref: EC:1.1.1.145
xref: MetaCyc:1.1.1.145-RXN
xref: Reactome:REACT_10031 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Homo sapiens"
xref: Reactome:REACT_10067 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Homo sapiens"
xref: Reactome:REACT_100839 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Danio rerio"
xref: Reactome:REACT_10090 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Homo sapiens"
xref: Reactome:REACT_10115 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Homo sapiens"
xref: Reactome:REACT_101983 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Bos taurus"
xref: Reactome:REACT_103390 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Bos taurus"
xref: Reactome:REACT_103657 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Sus scrofa"
xref: Reactome:REACT_103990 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Danio rerio"
xref: Reactome:REACT_104422 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Drosophila melanogaster"
xref: Reactome:REACT_104615 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Gallus gallus"
xref: Reactome:REACT_105565 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Mus musculus"
xref: Reactome:REACT_106120 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Bos taurus"
xref: Reactome:REACT_106214 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Danio rerio"
xref: Reactome:REACT_106644 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Taeniopygia guttata"
xref: Reactome:REACT_108035 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Canis familiaris"
xref: Reactome:REACT_108087 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Xenopus tropicalis"
xref: Reactome:REACT_108432 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Xenopus tropicalis"
xref: Reactome:REACT_109510 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Mus musculus"
xref: Reactome:REACT_111989 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Mycobacterium tuberculosis"
xref: Reactome:REACT_112248 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Escherichia coli"
xref: Reactome:REACT_113096 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Mycobacterium tuberculosis"
xref: Reactome:REACT_113257 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Escherichia coli"
xref: Reactome:REACT_113772 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Escherichia coli"
xref: Reactome:REACT_114424 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Escherichia coli"
xref: Reactome:REACT_114777 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Mycobacterium tuberculosis"
xref: Reactome:REACT_114921 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Mycobacterium tuberculosis"
xref: Reactome:REACT_115275 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Escherichia coli"
xref: Reactome:REACT_115303 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Mycobacterium tuberculosis"
xref: Reactome:REACT_28427 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Danio rerio"
xref: Reactome:REACT_28467 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Drosophila melanogaster"
xref: Reactome:REACT_29450 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Danio rerio"
xref: Reactome:REACT_30525 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Taeniopygia guttata"
xref: Reactome:REACT_30795 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Rattus norvegicus"
xref: Reactome:REACT_30899 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Canis familiaris"
xref: Reactome:REACT_32283 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Gallus gallus"
xref: Reactome:REACT_32783 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Mus musculus"
xref: Reactome:REACT_32924 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Gallus gallus"
xref: Reactome:REACT_33199 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Sus scrofa"
xref: Reactome:REACT_33352 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Gallus gallus"
xref: Reactome:REACT_34556 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Rattus norvegicus"
xref: Reactome:REACT_77900 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Drosophila melanogaster"
xref: Reactome:REACT_78893 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Xenopus tropicalis"
xref: Reactome:REACT_79104 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Sus scrofa"
xref: Reactome:REACT_79525 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Rattus norvegicus"
xref: Reactome:REACT_79553 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Bos taurus"
xref: Reactome:REACT_80359 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Drosophila melanogaster"
xref: Reactome:REACT_80746 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Rattus norvegicus"
xref: Reactome:REACT_81646 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Taeniopygia guttata"
xref: Reactome:REACT_82293 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Sus scrofa"
xref: Reactome:REACT_82688 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Mus musculus"
xref: Reactome:REACT_84251 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Canis familiaris"
xref: Reactome:REACT_85738 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Canis familiaris"
xref: Reactome:REACT_86717 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Drosophila melanogaster"
xref: Reactome:REACT_87612 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Taeniopygia guttata"
xref: Reactome:REACT_88118 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Mus musculus"
xref: Reactome:REACT_88292 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Rattus norvegicus"
xref: Reactome:REACT_88643 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Xenopus tropicalis"
xref: Reactome:REACT_91120 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Gallus gallus"
xref: Reactome:REACT_93787 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Taeniopygia guttata"
xref: Reactome:REACT_94450 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Xenopus tropicalis"
xref: Reactome:REACT_96507 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Sus scrofa"
xref: Reactome:REACT_99573 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Canis familiaris"
xref: Reactome:REACT_99689 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Bos taurus"
xref: Reactome:REACT_9989 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Homo sapiens"
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
AmiGO
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