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Category:GO:0002115 ! store-operated calcium entry
name: store-operated calcium entry
namespace: biological_process
def: "A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum." [GOC:hjd, PMID:11120592, PMID:17956991]
comment: SOCE is initiated by response to stiumlation of membrane receptors leading to the hydrolysis ofphosphatidylinositol bisphosphate (PIP2), inositol 1,4,5-trisphosphate (IP3) generation, and IP3-mediated calcium ion release from the endoplasmic reticulum.
synonym: "calcium ion import" BROAD []
synonym: "capacitative calcium entry" EXACT []
synonym: "SOCE" EXACT []
synonym: "store-operated calcium import" EXACT []
is_a: GO:0006816 ! calcium ion transport
AmiGO
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