Category:GO:0003714 ! transcription corepressor activity

name: transcription corepressor activity
namespace: molecular_function
alt_id: GO:0001106
def: "A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]
comment: For usage guidance, see comment in GO:0003712 ; transcription coregulator activity.
synonym: "RNA polymerase II transcription co-repressor activity" RELATED []
synonym: "RNA polymerase II transcription corepressor activity" RELATED []
synonym: "transcription co-repressor activity" EXACT []
is_a: GO:0003712 ! transcription coregulator activity
relationship: part_of: GO:0045892 ! negative regulation of DNA-templated transcription

AmiGO <GOterm>GO:0003714</GOterm>
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