CVHSA:R1AB

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Species (Taxon ID)	coronavirus). ([1])
Gene Name(s)	rep
Protein Name(s)	Replicase polyprotein 1ab pp1ab ORF1ab polyprotein Non-structural protein 1 nsp1 Leader protein Non-structural protein 2 nsp2 p65 homolog Non-structural protein 3 nsp3 PL2-PRO Papain-like proteinase PL-PRO SARS coronavirus main proteinase Non-structural protein 4 nsp4 3C-like proteinase 3CL-PRO 3CLp nsp5 Non-structural protein 6 nsp6 Non-structural protein 7 nsp7 Non-structural protein 8 nsp8 Non-structural protein 9 nsp9 Non-structural protein 10 nsp10 Growth factor-like peptide GFL RNA-directed RNA polymerase Pol RdRp nsp12 Helicase Hel nsp13 Exoribonuclease ExoN nsp14 Uridylate-specific endoribonuclease NendoU nsp15 Putative 2'-O-methyl transferase nsp16
External Links
EMBL	AY278741 AY278741 AY274119 AY278554 AY282752 AY304495 AY304486 AY304488 AY278491 AY283794 AY283795 AY283796 AY283797 AY283798 AY286320 AY278488 AY278489 AY278490 AY279354 AY291451 AY310120 AY291315 AY323977 AY321118 AY338174 AY338174 AY338175 AY338175 AY348314 AY348314 AP006557 AP006558 AP006559 AP006560 AP006561 AY427439 AY322205 AY322206 AY322207 AY463059 AY269391 AY268049
PDB	1O5S 1P76 1P9T 1PA5 1PUK 1Q1X 1Q2W 1QZ8 1SXF 1UJ1 1UK2 1UK3 1UK4 1UW7 1WOF 1YSY 1Z1I 1Z1J 2A5A 2A5I 2A5K 2ACF 2AHM 2AJ5 2ALV 2AMD 2AMQ 2BX3 2BX4 2C3S 2D2D 2DUC 2FAV 2FE8 2FYG 2G1F 2G9T 2GA6 2GDT 2GRI 2GT7 2GT8 2GTB 2GX4 2GZ7 2GZ8 2GZ9 2H2Z 2H85 2HOB 2HSX 2IDY 2JZD 2JZE 2JZF 2K87 2KAF 2OP9 2OZK 2PWX 2Q6G 2QC2 2QCY 2QIQ 2RHB 2RNK 2V6N 2VJ1 2YY4 2Z3C 2Z3D 2Z3E 2Z94 2Z9G 2Z9J 2Z9K 2Z9L 3D62 3E9S 3EBN
PDBsum	1O5S 1P76 1P9T 1PA5 1PUK 1Q1X 1Q2W 1QZ8 1SXF 1UJ1 1UK2 1UK3 1UK4 1UW7 1WOF 1YSY 1Z1I 1Z1J 2A5A 2A5I 2A5K 2ACF 2AHM 2AJ5 2ALV 2AMD 2AMQ 2BX3 2BX4 2C3S 2D2D 2DUC 2FAV 2FE8 2FYG 2G1F 2G9T 2GA6 2GDT 2GRI 2GT7 2GT8 2GTB 2GX4 2GZ7 2GZ8 2GZ9 2H2Z 2H85 2HOB 2HSX 2IDY 2JZD 2JZE 2JZF 2K87 2KAF 2OP9 2OZK 2PWX 2Q6G 2QC2 2QCY 2QIQ 2RHB 2RNK 2V6N 2VJ1 2YY4 2Z3C 2Z3D 2Z3E 2Z94 2Z9G 2Z9J 2Z9K 2Z9L 3D62 3E9S 3EBN
ProteinModelPortal	P0C6X7
SMR	P0C6X7
MINT	MINT-1487760
BindingDB	P0C6X7
GO	GO:0044172 GO:0033644 GO:0044220 GO:0016021 GO:0048471 GO:0019034 GO:0005524 GO:0004197 GO:0004519 GO:0016896 GO:0004386 GO:0008168 GO:0008242 GO:0003723 GO:0003968 GO:0008270 GO:0030683 GO:0006508 GO:0006351 GO:0019079 GO:0019082
InterPro	IPR002589 IPR009461 IPR000606 IPR021590 IPR009466 IPR024375 IPR014828 IPR014829 IPR014822 IPR009003 IPR008740 IPR013016 IPR001205 IPR007094 IPR009469 IPR018995 IPR024358 IPR022733 IPR014827
Pfam	PF06478 PF12379 PF01661 PF11501 PF09401 PF06471 PF06460 PF11633 PF12124 PF08716 PF08717 PF08710 PF05409 PF00680 PF01443 PF08715
SUPFAM	SSF101816 SSF50494 SSF144246
PROSITE	PS51442 PS51154 PS51124 PS50507

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F	Seeded From UniProt
	GO:0003723	RNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001205	F	Seeded From UniProt
	GO:0003723	RNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009469	F	Seeded From UniProt
	GO:0003723	RNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014822	F	Seeded From UniProt
	GO:0003723	RNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018995	F	Seeded From UniProt
	GO:0003723	RNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0694	F	Seeded From UniProt
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009003	F	Seeded From UniProt
	GO:0003968	RNA-directed RNA polymerase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001205	F	Seeded From UniProt
	GO:0003968	RNA-directed RNA polymerase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007094	F	Seeded From UniProt
	GO:0003968	RNA-directed RNA polymerase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009461	F	Seeded From UniProt
	GO:0003968	RNA-directed RNA polymerase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009466	F	Seeded From UniProt
	GO:0003968	RNA-directed RNA polymerase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009469	F	Seeded From UniProt
	GO:0003968	RNA-directed RNA polymerase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013016	F	Seeded From UniProt
	GO:0003968	RNA-directed RNA polymerase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.7.7.48	F	Seeded From UniProt
	GO:0003968	RNA-directed RNA polymerase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0696	F	Seeded From UniProt
	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009461	F	Seeded From UniProt
	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009466	F	Seeded From UniProt
	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014827	F	Seeded From UniProt
	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014828	F	Seeded From UniProt
	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014829	F	Seeded From UniProt
	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR021590	F	Seeded From UniProt
	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR022733	F	Seeded From UniProt
	GO:0004386	helicase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000606	F	Seeded From UniProt
	GO:0004386	helicase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0347	F	Seeded From UniProt
	GO:0004518	nuclease activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0540	F	Seeded From UniProt
	GO:0004519	endonuclease activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0255	F	Seeded From UniProt
	GO:0004527	exonuclease activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0269	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009469	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F	Seeded From UniProt
	GO:0006351	transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001205	P	Seeded From UniProt
	GO:0006351	transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009469	P	Seeded From UniProt
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013016	P	Seeded From UniProt
	GO:0006508	proteolysis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0645	P	Seeded From UniProt
	GO:0008168	methyltransferase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009461	F	Seeded From UniProt
	GO:0008168	methyltransferase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009466	F	Seeded From UniProt
	GO:0008233	peptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009461	F	Seeded From UniProt
	GO:0008233	peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0645	F	Seeded From UniProt
	GO:0008234	cysteine-type peptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013016	F	Seeded From UniProt
	GO:0008234	cysteine-type peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0788	F	Seeded From UniProt
	GO:0008242	omega peptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014827	F	Seeded From UniProt
	GO:0008242	omega peptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014828	F	Seeded From UniProt
	GO:0008242	omega peptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014829	F	Seeded From UniProt
	GO:0008242	omega peptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR021590	F	Seeded From UniProt
	GO:0008242	omega peptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR022733	F	Seeded From UniProt
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018995	F	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded From UniProt
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded From UniProt
	GO:0016740	transferase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014827	F	Seeded From UniProt
	GO:0016740	transferase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014828	F	Seeded From UniProt
	GO:0016740	transferase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014829	F	Seeded From UniProt
	GO:0016740	transferase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR021590	F	Seeded From UniProt
	GO:0016740	transferase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR022733	F	Seeded From UniProt
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F	Seeded From UniProt
	GO:0016779	nucleotidyltransferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0548	F	Seeded From UniProt
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F	Seeded From UniProt
	GO:0016788	hydrolase activity, acting on ester bonds	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR021590	F	Seeded From UniProt
	GO:0016788	hydrolase activity, acting on ester bonds	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR022733	F	Seeded From UniProt
	GO:0016817	hydrolase activity, acting on acid anhydrides	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009461	F	Seeded From UniProt
	GO:0016817	hydrolase activity, acting on acid anhydrides	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR021590	F	Seeded From UniProt
	GO:0016817	hydrolase activity, acting on acid anhydrides	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR022733	F	Seeded From UniProt
	GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009461	F	Seeded From UniProt
	GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009466	F	Seeded From UniProt
	GO:0019034	viral replication complex	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014822	C	Seeded From UniProt
	GO:0019079	viral genome replication	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007094	P	Seeded From UniProt
	GO:0019079	viral genome replication	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014822	P	Seeded From UniProt
	GO:0019079	viral genome replication	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018995	P	Seeded From UniProt
	GO:0019082	viral protein processing	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008740	P	Seeded From UniProt
	GO:0030430	host cell cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1035	C	Seeded From UniProt
	GO:0030683	evasion by virus of host immune response	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0899	P	Seeded From UniProt
	GO:0032259	methylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009461	P	Seeded From UniProt
	GO:0032259	methylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009466	P	Seeded From UniProt
	GO:0032774	RNA biosynthetic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0693	P	Seeded From UniProt
	GO:0033644	host cell membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1043	C	Seeded From UniProt
	GO:0033644	host cell membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0380	C	Seeded From UniProt
	GO:0044172	host cell endoplasmic reticulum-Golgi intermediate compartment	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0391	C	Seeded From UniProt
	GO:0044220	host cell perinuclear region of cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0382	C	Seeded From UniProt
	GO:0044419	interspecies interaction between organisms	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0945	P	Seeded From UniProt
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F	Seeded From UniProt
	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018995	C	Seeded From UniProt
	GO:0000175	3'-5'-exoribonuclease activity	PMID:16549795^[1]	IDA: Inferred from Direct Assay		F	Fig. 3 and Fig. 4	complete
	GO:0019083	viral transcription	PMID:16549795^[1]	IMP: Inferred from Mutant Phenotype		P	Fig. 5	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Minskaia E et al. (2006) Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesis. Proc Natl Acad Sci U S A 103: 5108-13 PubMed GONUTS page

[PMID:16549795-0] 1.0 ^1.1 Minskaia E et al. (2006) Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesis. Proc Natl Acad Sci U S A 103: 5108-13 PubMed GONUTS page

[1]

CVHSA:R1AB

Contents

Annotations

Notes

References

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