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CLOBO:BXA2
Contents |
| Species (Taxon ID) | Clostridium botulinum. ([1]) | |
| Gene Name(s) | botA (synonyms: atx, bna) | |
| Protein Name(s) | Botulinum neurotoxin type A
BoNT/A Bontoxilysin-A BOTOX Botulinum neurotoxin A light chain Botulinum neurotoxin A heavy chain | |
| External Links | ||
| EMBL | X73423 X87974 | |
| PIR | I40645 | |
| RefSeq | YP_002803127.1 | |
| PDB | 1E1H 2G7K 2G7N 2G7P 2G7Q | |
| PDBsum | 1E1H 2G7K 2G7N 2G7P 2G7Q | |
| ProteinModelPortal | Q45894 | |
| SMR | Q45894 | |
| DIP | DIP-437N | |
| GeneID | 7766540 | |
| ProtClustDB | CLSK912378 | |
| BindingDB | Q45894 | |
| GO | GO:0044164 GO:0044156 GO:0044231 GO:0016021 GO:0004222 GO:0050827 GO:0008270 GO:0051609 GO:0009405 GO:0006508 | |
| InterPro | IPR008985 IPR013320 IPR011065 IPR000395 IPR013104 IPR012928 IPR012500 | |
| Gene3D | G3DSA:2.60.120.200 G3DSA:3.90.1240.10 | |
| Pfam | PF01742 PF07951 PF07953 PF07952 | |
| PRINTS | PR00760 | |
| SUPFAM | SSF49899 SSF50386 | |
| PROSITE | PS00142 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0004222 |
metalloendopeptidase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004222 |
metalloendopeptidase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004222 |
metalloendopeptidase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0243 |
C |
Seeded From UniProt |
|||
| GO:0006508 |
proteolysis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006508 |
proteolysis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0008233 |
peptidase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0008237 |
metallopeptidase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0008270 |
zinc ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0009405 |
pathogenesis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0009405 |
pathogenesis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0009405 |
pathogenesis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0009405 |
pathogenesis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016787 |
hydrolase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0020002 |
host cell plasma membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0030430 |
host cell cytoplasm |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0033644 |
host cell membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0044156 |
host cell junction |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0044164 |
host cell cytosol |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0384 |
C |
Seeded From UniProt |
|||
| GO:0044221 |
host cell synapse |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0044231 |
host cell presynaptic membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0434 |
C |
Seeded From UniProt |
|||
| GO:0046872 |
metal ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0050827 |
toxin receptor binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0051609 |
inhibition of neurotransmitter uptake |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006508 |
proteolysis |
EXP: Inferred from Experiment |
P |
Figure 2: Botulinum toxin proteolytic activity on VAMP. |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Sikorra S et al. (2008) Substrate recognition mechanism of VAMP/synaptobrevin-cleaving clostridial neurotoxins. J Biol Chem 283: 21145-52 PubMed GONUTS page
eh |
h cont.im |
m cont.ptz |
