CHICK:VINC

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Species (Taxon ID)	Gallus gallus (Chicken). (taxon:9031)
Gene Name(s)	VCL ( synonyms: VINC1 )
Protein Name(s)	Vinculin Metavinculin
External Links
UniProt Identifier	VINC_CHICK
UniProt Accessions	P12003, Q91024,
EMBL	J04126, M87837, Y00312,
PIR	A31346,
RefSeq	NP_990772.1,
PDB	1QKR, 1ST6, 1T01, 1U6H, 1XWJ, 1ZVZ, 1ZW2, 1ZW3, 2GDC,
IntAct	P12003,
Pfam	PF01044,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0002009	morphogenesis of an epithelium	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000211998	P
	GO:0002009	morphogenesis of an epithelium	PMID:20086044^[1]	IDA: Inferred from Direct Assay		P
	GO:0002166	beta-dystroglycan binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000211998	F
	GO:0003779	actin binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0009	F
	GO:0005198	structural molecule activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000633	F
	GO:0005198	structural molecule activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006077	F
	GO:0005198	structural molecule activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017997	F
	GO:0005515	protein binding	PMID:10320340^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q80XB4	F
	GO:0005515	protein binding	PMID:10545097^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P18010	F
	GO:0005515	protein binding	PMID:15272303^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P26039	F
	GO:0005515	protein binding	PMID:18854161^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q9QXZ0	F
	GO:0005576	extracellular region	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000211998	C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005743	mitochondrial inner membrane	PMID:12615910^[6]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000211998	C
	GO:0005856	cytoskeleton	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0206	C
	GO:0005856	cytoskeleton	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0090	C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000022369	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005911	cell-cell junction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000022369	C
	GO:0005911	cell-cell junction	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q64727	C
	GO:0005911	cell-cell junction	PMID:20584916^[7]	IDA: Inferred from Direct Assay		C
	GO:0005912	adherens junction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000022369	C
	GO:0005912	adherens junction	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0009	C
	GO:0005912	adherens junction	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q64727	C
	GO:0005913	cell-cell adherens junction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000211998	C
	GO:0005916	fascia adherens	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000022369	C
	GO:0005925	focal adhesion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000022369	C
	GO:0005925	focal adhesion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000211998	C
	GO:0005925	focal adhesion	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q64727	C
	GO:0006936	muscle contraction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000211998	P
	GO:0007155	cell adhesion	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000633	P
	GO:0007155	cell adhesion	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006077	P
	GO:0007155	cell adhesion	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017997	P
	GO:0007155	cell adhesion	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0130	P
	GO:0007155	cell adhesion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000022369	P
	GO:0008013	beta-catenin binding	PMID:20086044^[1]	IDA: Inferred from Direct Assay		F
	GO:0015629	actin cytoskeleton	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000633	C
	GO:0015629	actin cytoskeleton	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006077	C
	GO:0015629	actin cytoskeleton	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017997	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0030032	lamellipodium assembly	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000022369	P
	GO:0030032	lamellipodium assembly	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q64727	P
	GO:0030054	cell junction	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0965	C
	GO:0030334	regulation of cell migration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000022369	P
	GO:0030334	regulation of cell migration	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q64727	P
	GO:0034333	adherens junction assembly	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000211998	P
	GO:0034333	adherens junction assembly	PMID:20086044^[1]	IDA: Inferred from Direct Assay		P
	GO:0034394	protein localization at cell surface	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000211998	P
	GO:0043034	costamere	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000022369	C
	GO:0043034	costamere	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000211998	C
	GO:0043034	costamere	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q64727	C
	GO:0043234	protein complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000211998	C
	GO:0043297	apical junction assembly	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000211998	P
	GO:0045294	alpha-catenin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000211998	F
	GO:0045294	alpha-catenin binding	PMID:20086044^[1]	IDA: Inferred from Direct Assay		F
	GO:0045296	cadherin binding	PMID:20086044^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P12830	F
	GO:0090136	epithelial cell-cell adhesion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000211998	P
	GO:0090136	epithelial cell-cell adhesion	PMID:20086044^[1]	IDA: Inferred from Direct Assay		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Peng X et al. (2010) Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin. J Cell Sci 123: 567-77 PubMed GONUTS page
↑ Luo G et al. (1999) Molecular interactions of N-RAP, a nebulin-related protein of striated muscle myotendon junctions and intercalated disks. Biochemistry 38: 6135-43 PubMed GONUTS page
↑ Bourdet-Sicard R et al. (1999) Binding of the Shigella protein IpaA to vinculin induces F-actin depolymerization. EMBO J 18: 5853-62 PubMed GONUTS page
↑ Papagrigoriou E et al. (2004) Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle. EMBO J 23: 2942-51 PubMed GONUTS page
↑ Wu X et al. (2008) ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity. Cell 135: 137-48 PubMed GONUTS page
↑ Miyazaki T et al. (2003) Regulation of cytochrome c oxidase activity by c-Src in osteoclasts. J Cell Biol 160: 709-18 PubMed GONUTS page
↑ le Duc Q et al. (2010) Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner. J Cell Biol 189: 1107-15 PubMed GONUTS page

[PMID:20086044-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Peng X et al. (2010) Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin. J Cell Sci 123: 567-77 PubMed GONUTS page

[PMID:10320340-1] Luo G et al. (1999) Molecular interactions of N-RAP, a nebulin-related protein of striated muscle myotendon junctions and intercalated disks. Biochemistry 38: 6135-43 PubMed GONUTS page

[PMID:10545097-2] Bourdet-Sicard R et al. (1999) Binding of the Shigella protein IpaA to vinculin induces F-actin depolymerization. EMBO J 18: 5853-62 PubMed GONUTS page

[PMID:15272303-3] Papagrigoriou E et al. (2004) Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle. EMBO J 23: 2942-51 PubMed GONUTS page

[PMID:18854161-4] Wu X et al. (2008) ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity. Cell 135: 137-48 PubMed GONUTS page

[PMID:12615910-5] Miyazaki T et al. (2003) Regulation of cytochrome c oxidase activity by c-Src in osteoclasts. J Cell Biol 160: 709-18 PubMed GONUTS page

[PMID:20584916-6] Duc Q et al. (2010) Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner. J Cell Biol 189: 1107-15 PubMed GONUTS page

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CHICK:VINC

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