CHICK:TLN1

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Species (Taxon ID)	Gallus gallus (Chicken). (taxon:9031)
Gene Name(s)	TLN1 ( synonyms: TLN )
Protein Name(s)	Talin-1
External Links
UniProt Identifier	TLN1_CHICK
UniProt Accessions	P54939, Q8AWI0,
EMBL	AY150847,
PIR	B42965, D42965,
RefSeq	NP_989854.1,
PDB	1MIX, 1MIZ, 1MK7, 1MK9, 1RKC, 1U6H, 1XWJ, 1ZVZ, 1ZW2, 2H7D, 2H7E, 2HRJ, 2K00,
IntAct	P54939,
Pfam	PF00373, PF09379, PF01608, PF02174, PF09141, PF08913,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0001726	ruffle	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015224	C
	GO:0001726	ruffle	PMID:9786953^[1]	IDA: Inferred from Direct Assay		C
	GO:0003779	actin binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002558	F
	GO:0005158	insulin receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002404	F
	GO:0005198	structural molecule activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006077	F
	GO:0005200	structural constituent of cytoskeleton	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015224	F
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014352	F
	GO:0005515	protein binding	PMID:12535520^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P05106	F
	GO:0005515	protein binding	PMID:14702644^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P18206	F
	GO:0005515	protein binding	PMID:9786953^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q05397	F
	GO:0005515	protein binding	PMID:9786953^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Z209	F
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005829	cytosol	PMID:9786953^[1]	TAS: Traceable Author Statement		C
	GO:0005856	cytoskeleton	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000299	C
	GO:0005856	cytoskeleton	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0206	C
	GO:0005856	cytoskeleton	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0090	C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005925	focal adhesion	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015224	C
	GO:0005925	focal adhesion	PMID:9786953^[1]	IDA: Inferred from Direct Assay		C
	GO:0007016	cytoskeletal anchoring at plasma membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015224	P
	GO:0007155	cell adhesion	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006077	P
	GO:0015629	actin cytoskeleton	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006077	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0032587	ruffle membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0301	C
	GO:0042995	cell projection	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0966	C
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Borowsky ML & Hynes RO (1998) Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles. J Cell Biol 143: 429-42 PubMed GONUTS page
↑ García-Alvarez B et al. (2003) Structural determinants of integrin recognition by talin. Mol Cell 11: 49-58 PubMed GONUTS page
↑ Izard T et al. (2004) Vinculin activation by talin through helical bundle conversion. Nature 427: 171-5 PubMed GONUTS page

[PMID:9786953-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Borowsky ML & Hynes RO (1998) Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles. J Cell Biol 143: 429-42 PubMed GONUTS page

[PMID:12535520-1] García-Alvarez B et al. (2003) Structural determinants of integrin recognition by talin. Mol Cell 11: 49-58 PubMed GONUTS page

[PMID:14702644-2] Izard T et al. (2004) Vinculin activation by talin through helical bundle conversion. Nature 427: 171-5 PubMed GONUTS page

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CHICK:TLN1

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