CHICK:TGFR2

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Species (Taxon ID)	Gallus gallus (Chicken). (taxon:9031)
Gene Name(s)	TGFBR2
Protein Name(s)	TGF-beta receptor type-2 TGFR-2 TGF-beta type II receptor Transforming growth factor-beta receptor type II TGF-beta receptor type II TbetaR-II
External Links
UniProt Identifier	TGFR2_CHICK
UniProt Accessions	Q90999,
EMBL	L18784,
PIR	I50429,
RefSeq	NP_990759.1,
PDB	1KS6,
Ensembl	ENSGALT00000018657,
Pfam	PF08917, PF00069,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0001569	patterning of blood vessels	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0001570	vasculogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0001654	eye development	PMID:8167376^[1]	IEP: Inferred from Expression Pattern		P
	GO:0001701	in utero embryonic development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0001775	cell activation	PMID:8631497^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0002651	positive regulation of tolerance induction to self antigen	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0002663	positive regulation of B cell tolerance induction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0002666	positive regulation of T cell tolerance induction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017194	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0723	F
	GO:0004702	receptor signaling protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000333	F
	GO:0004872	receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017194	F
	GO:0004872	receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0675	F
	GO:0005026	transforming growth factor beta receptor activity, type II	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015013	F
	GO:0005515	protein binding	PMID:10885742^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q90ZK6	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000333	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015013	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005623	cell	PMID:10075204^[4]	IDA: Inferred from Direct Assay		C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015013	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	P
	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000333	P
	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017194	P
	GO:0007224	smoothened signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0007369	gastrulation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0007420	brain development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0007507	heart development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0007507	heart development	PMID:8167376^[1]	IEP: Inferred from Expression Pattern		P
	GO:0007507	heart development	PMID:8631497^[2]	IEP: Inferred from Expression Pattern		P
	GO:0009790	embryo development	PMID:8167376^[1]	IEP: Inferred from Expression Pattern		P
	GO:0009897	external side of plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	C
	GO:0009897	external side of plasma membrane	PMID:12589747^[5]	TAS: Traceable Author Statement		C
	GO:0010718	positive regulation of epithelial to mesenchymal transition	PMID:8631497^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000333	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015013	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017194	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P
	GO:0016477	cell migration	PMID:10885742^[3]	TAS: Traceable Author Statement		P
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F
	GO:0030324	lung development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0030324	lung development	PMID:8167376^[1]	IEP: Inferred from Expression Pattern		P
	GO:0030335	positive regulation of cell migration	PMID:17587820^[6]	TAS: Traceable Author Statement		P
	GO:0030335	positive regulation of cell migration	PMID:8631497^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0032147	activation of protein kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0035162	embryonic hemopoiesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0042127	regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0043011	myeloid dendritic cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0043235	receptor complex	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017194	C
	GO:0046332	SMAD binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	F
	GO:0046872	metal ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015013	F
	GO:0046872	metal ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017194	F
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0048701	embryonic cranial skeleton morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0048762	mesenchymal cell differentiation	PMID:10885742^[3]	TAS: Traceable Author Statement		P
	GO:0048762	mesenchymal cell differentiation	PMID:8631497^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0050431	transforming growth factor beta binding	PMID:8167376^[1]	IMP: Inferred from Mutant Phenotype		F
	GO:0051138	positive regulation of NK T cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0060021	palate development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0060317	cardiac epithelial to mesenchymal transition	PMID:17587820^[6]	TAS: Traceable Author Statement		P
	GO:0060317	cardiac epithelial to mesenchymal transition	PMID:8631497^[2]	IEP: Inferred from Expression Pattern		P
	GO:0060425	lung morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0060433	bronchus development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0060434	bronchus morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0060439	trachea morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0060440	trachea formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0060443	mammary gland morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0060463	lung lobe morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
	GO:0070723	response to cholesterol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000062333	P
NOT	GO:0007162	negative regulation of cell adhesion	PMID:17587820^[6]	TAS: Traceable Author Statement		P
NOT	GO:0010468	regulation of gene expression	PMID:11500982^[7]	IMP: Inferred from Mutant Phenotype	UniProtKB:P07228	P
NOT	GO:0022408	negative regulation of cell-cell adhesion	PMID:11500982^[7]	IMP: Inferred from Mutant Phenotype		P
contributes_to	GO:0034713	type I transforming growth factor beta receptor binding	PMID:10885742^[3]	IDA: Inferred from Direct Assay		F
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Barnett JV et al. (1994) Cloning and developmental expression of the chick type II and type III TGF beta receptors. Dev Dyn 199: 12-27 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Brown CB et al. (1996) Antibodies to the Type II TGFbeta receptor block cell activation and migration during atrioventricular cushion transformation in the heart. Dev Biol 174: 248-57 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Lai YT et al. (2000) Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation. Dev Biol 222: 1-11 PubMed GONUTS page
↑ Richiert DM & Ireland ME (1999) TGF-beta elicits fibronectin secretion and proliferation in cultured chick lens epithelial cells. Curr Eye Res 18: 62-71 PubMed GONUTS page
↑ Marlow MS et al. (2003) Solution structure of the chick TGFbeta type II receptor ligand-binding domain. J Mol Biol 326: 989-97 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Mercado-Pimentel ME & Runyan RB (2007) Multiple transforming growth factor-beta isoforms and receptors function during epithelial-mesenchymal cell transformation in the embryonic heart. Cells Tissues Organs 185: 146-56 PubMed GONUTS page
↑ ^7.0 ^7.1 Boyer AS & Runyan RB (2001) TGFbeta Type III and TGFbeta Type II receptors have distinct activities during epithelial-mesenchymal cell transformation in the embryonic heart. Dev Dyn 221: 454-9 PubMed GONUTS page

[PMID:8167376-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Barnett JV et al. (1994) Cloning and developmental expression of the chick type II and type III TGF beta receptors. Dev Dyn 199: 12-27 PubMed GONUTS page

[PMID:8631497-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Brown CB et al. (1996) Antibodies to the Type II TGFbeta receptor block cell activation and migration during atrioventricular cushion transformation in the heart. Dev Biol 174: 248-57 PubMed GONUTS page

[PMID:10885742-2] 3.0 ^3.1 ^3.2 ^3.3 Lai YT et al. (2000) Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation. Dev Biol 222: 1-11 PubMed GONUTS page

[PMID:10075204-3] Richiert DM & Ireland ME (1999) TGF-beta elicits fibronectin secretion and proliferation in cultured chick lens epithelial cells. Curr Eye Res 18: 62-71 PubMed GONUTS page

[PMID:12589747-4] Marlow MS et al. (2003) Solution structure of the chick TGFbeta type II receptor ligand-binding domain. J Mol Biol 326: 989-97 PubMed GONUTS page

[PMID:17587820-5] 6.0 ^6.1 ^6.2 Mercado-Pimentel ME & Runyan RB (2007) Multiple transforming growth factor-beta isoforms and receptors function during epithelial-mesenchymal cell transformation in the embryonic heart. Cells Tissues Organs 185: 146-56 PubMed GONUTS page

[PMID:11500982-6] 7.0 ^7.1 Boyer AS & Runyan RB (2001) TGFbeta Type III and TGFbeta Type II receptors have distinct activities during epithelial-mesenchymal cell transformation in the embryonic heart. Dev Dyn 221: 454-9 PubMed GONUTS page

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CHICK:TGFR2

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