CHICK:SOX2

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Species (Taxon ID)	Gallus gallus (Chicken). (taxon:9031)
Gene Name(s)	SOX2
Protein Name(s)	Transcription factor SOX-2 cSox2 delta EF2a
External Links
UniProt Identifier	SOX2_CHICK
UniProt Accessions	P48430, Q54A48,
EMBL	U12532, D50603, AB092842,
PIR	I50706,
RefSeq	NP_990519.1,
Ensembl	ENSGALT00000014379,
Pfam	PF00505, PF12336,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0001649	osteoblast differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000439111	P
	GO:0001654	eye development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000439111	P
	GO:0001708	cell fate specification	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0002052	positive regulation of neuroblast proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000910	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003677	DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	F
	GO:0003677	DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000439111	F
	GO:0003682	chromatin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000439111	F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:7628452^[1]	IDA: Inferred from Direct Assay		C
	GO:0005667	transcription factor complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000439111	C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000439111	C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006351	transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0006351	transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000439111	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000439111	P
	GO:0007050	cell cycle arrest	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000439111	P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0007605	sensory perception of sound	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0009611	response to wounding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000439111	P
	GO:0010468	regulation of gene expression	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000439111	P
	GO:0019827	stem cell maintenance	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0021879	forebrain neuron differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0021983	pituitary gland development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000439111	P
	GO:0021984	adenohypophysis development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0021987	cerebral cortex development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0030178	negative regulation of Wnt receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0030539	male genitalia development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0030858	positive regulation of epithelial cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0030900	forebrain development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000439111	P
	GO:0030910	olfactory placode formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0032526	response to retinoic acid	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0035019	somatic stem cell maintenance	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000439111	P
	GO:0035198	miRNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000439111	F
	GO:0042221	response to chemical stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0042472	inner ear morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0043281	regulation of caspase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000439111	P
	GO:0043410	positive regulation of MAPKKK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000439111	P
	GO:0043565	sequence-specific DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	F
	GO:0043565	sequence-specific DNA binding	PMID:7628452^[1]	IDA: Inferred from Direct Assay		F
	GO:0043586	tongue development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0045165	cell fate commitment	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0045596	negative regulation of cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0045665	negative regulation of neuron differentiation	PMID:14517545^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0045666	positive regulation of neuron differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0045668	negative regulation of osteoblast differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0045747	positive regulation of Notch signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0045893	positive regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000439111	P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:7628452^[1]	IDA: Inferred from Direct Assay		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000439111	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:7628452^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0046148	pigment biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0048286	lung alveolus development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0048568	embryonic organ development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0048646	anatomical structure formation involved in morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0048663	neuron fate commitment	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0048839	inner ear development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000439111	P
	GO:0048852	diencephalon morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000439111	P
	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0050973	detection of mechanical stimulus involved in equilibrioception	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0060042	retina morphogenesis in camera-type eye	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0060235	lens induction in camera-type eye	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0060441	epithelial tube branching involved in lung morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096755	P
	GO:0070848	response to growth factor stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000439111	P
	GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000439111	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Kamachi Y et al. (1995) Involvement of SOX proteins in lens-specific activation of crystallin genes. EMBO J 14: 3510-9 PubMed GONUTS page
↑ Bylund M et al. (2003) Vertebrate neurogenesis is counteracted by Sox1-3 activity. Nat Neurosci 6: 1162-8 PubMed GONUTS page

[PMID:7628452-0] 1.0 ^1.1 ^1.2 ^1.3 Kamachi Y et al. (1995) Involvement of SOX proteins in lens-specific activation of crystallin genes. EMBO J 14: 3510-9 PubMed GONUTS page

[PMID:14517545-1] Bylund M et al. (2003) Vertebrate neurogenesis is counteracted by Sox1-3 activity. Nat Neurosci 6: 1162-8 PubMed GONUTS page

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CHICK:SOX2

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