GONUTS has been updated to MW1.29.2. Most things seem to be working but be sure to report problems.

It is now the 6th OPEN Period for CACAO Spring 2018! It will end on Monday April 23, 2018 at 05:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

It is now the 4th OPEN Period for CACAO Phage Hunters 2018! It will end on Sunday April 22, 2018 at 11:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

Have any questions? Please email us at ecoliwiki@gmail.com

CHICK:Q9PUI3

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) WNT2B
Protein Name(s) Protein Wnt-2b
External Links
UniProt Q98SN7
EMBL AF346628
AF182403
RefSeq NP_989667.1
UniGene Gga.50310
IntAct Q98SN7
STRING 9031.ENSGALP00000039420
PaxDb Q98SN7
PRIDE Q98SN7
GeneID 374243
KEGG gga:374243
CTD 7482
eggNOG NOG284879
HOGENOM HOG000039529
HOVERGEN HBG001595
InParanoid Q98SN7
KO K00182
PhylomeDB Q98SN7
NextBio 20813739
PRO PR:Q98SN7
Proteomes UP000000539
GO GO:0005578
GO:0005109
GO:0060219
GO:0060070
GO:0008283
GO:0061303
GO:0060900
GO:0035115
GO:0061072
GO:0002088
GO:0002011
GO:0045686
GO:0045665
GO:0003407
GO:0030182
GO:0045743
GO:0060828
GO:0010842
GO:0016055
InterPro IPR005817
IPR009140
IPR018161
PANTHER PTHR12027
Pfam PF00110
PRINTS PR01842
PR01349
SMART SM00097
PROSITE PS00246

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0002011

morphogenesis of an epithelial sheet

PMID:12921742[1]

IDA: Inferred from Direct Assay

P

complete

GO:0002088

lens development in camera-type eye

PMID:16258938[2]

IEP: Inferred from Expression Pattern

P

complete

GO:0003407

neural retina development

PMID:15901663[3]

TAS: Traceable Author Statement

P

complete

GO:0004871

signal transducer activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009140

F

complete

GO:0005109

frizzled binding

PMID:12490564[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q13467

F

complete

GO:0005109

frizzled binding

PMID:12490564[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q61088

F

complete

GO:0005575

cellular component

GO_REF:0000015

ND: No biological Data available

C

complete

GO:0005576

extracellular region

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005816

C

complete

GO:0005576

extracellular region

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005817

C

complete

GO:0005576

extracellular region

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009140

C

complete

GO:0005576

extracellular region

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0964

C

complete

GO:0005578

proteinaceous extracellular matrix

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0272

C

complete

GO:0005578

proteinaceous extracellular matrix

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0111

C

complete

GO:0007223

Wnt receptor signaling pathway, calcium modulating pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005816

P

complete

GO:0007223

Wnt receptor signaling pathway, calcium modulating pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005817

P

complete

GO:0007223

Wnt receptor signaling pathway, calcium modulating pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009140

P

complete

GO:0007275

multicellular organismal development

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005816

P

complete

GO:0007275

multicellular organismal development

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005817

P

complete

GO:0007275

multicellular organismal development

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009140

P

complete

GO:0007275

multicellular organismal development

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0217

P

complete

GO:0008283

cell proliferation

PMID:10398532[5]

IEP: Inferred from Expression Pattern

P

complete

GO:0008283

cell proliferation

PMID:12490564[4]

IDA: Inferred from Direct Assay

P

complete

GO:0008283

cell proliferation

PMID:15901663[3]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0010842

retina layer formation

PMID:12921742[1]

IDA: Inferred from Direct Assay

P

complete

GO:0016055

Wnt receptor signaling pathway

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0879

P

complete

GO:0016055

Wnt receptor signaling pathway

PMID:12921742[1]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0030182

neuron differentiation

PMID:16854977[6]

IEP: Inferred from Expression Pattern

P

complete

GO:0035115

embryonic forelimb morphogenesis

PMID:11290326[7]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0045665

negative regulation of neuron differentiation

PMID:12490564[4]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0045665

negative regulation of neuron differentiation

PMID:12921742[1]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0045665

negative regulation of neuron differentiation

PMID:15901663[3]

IDA: Inferred from Direct Assay

P

complete

GO:0045686

negative regulation of glial cell differentiation

PMID:15901663[3]

IDA: Inferred from Direct Assay

P

complete

GO:0045743

positive regulation of fibroblast growth factor receptor signaling pathway

PMID:11290326[7]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0060070

canonical Wnt receptor signaling pathway

PMID:12490564[4]

IDA: Inferred from Direct Assay

P

complete

GO:0060070

canonical Wnt receptor signaling pathway

PMID:16854977[6]

IDA: Inferred from Direct Assay

P

complete

GO:0060219

camera-type eye photoreceptor cell differentiation

PMID:16854977[6]

IEP: Inferred from Expression Pattern

P

complete

GO:0060828

regulation of canonical Wnt receptor signaling pathway

PMID:11290326[7]

IDA: Inferred from Direct Assay

P

complete

GO:0060900

embryonic camera-type eye formation

PMID:12921742[1]

IEP: Inferred from Expression Pattern

P

complete

GO:0061072

iris morphogenesis

PMID:16258938[2]

IEP: Inferred from Expression Pattern

P

complete

GO:0002011

morphogenesis of an epithelial sheet

PMID:12921742[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0061303

cornea development in camera-type eye

PMID:16258938[2]

IEP: Inferred from Expression Pattern

P

complete

GO:0002088

lens development in camera-type eye

PMID:16258938[2]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0003407

neural retina development

PMID:15901663[3]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0005102

receptor binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005817
InterPro:IPR009140

F

Seeded From UniProt

complete

GO:0005109

frizzled binding

PMID:12490564[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q13467

F

Seeded From UniProt

complete

GO:0005109

frizzled binding

PMID:12490564[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q61088

F

Seeded From UniProt

complete

GO:0005576

extracellular region

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005817
InterPro:IPR009140

C

Seeded From UniProt

complete

GO:0005576

extracellular region

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

GO:0005578

proteinaceous extracellular matrix

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0272

C

Seeded From UniProt

complete

GO:0005578

proteinaceous extracellular matrix

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0111

C

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005817
InterPro:IPR009140

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0008283

cell proliferation

PMID:10398532[5]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0008283

cell proliferation

PMID:12490564[4]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0008283

cell proliferation

PMID:15901663[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0010842

retina layer formation

PMID:12921742[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0016055

Wnt signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005817
InterPro:IPR009140

P

Seeded From UniProt

complete

GO:0016055

Wnt signaling pathway

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

GO:0016055

Wnt signaling pathway

PMID:12921742[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030182

neuron differentiation

PMID:16854977[6]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0035115

embryonic forelimb morphogenesis

PMID:11290326[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045665

negative regulation of neuron differentiation

PMID:12490564[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045665

negative regulation of neuron differentiation

PMID:12921742[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045665

negative regulation of neuron differentiation

PMID:15901663[3]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0045686

negative regulation of glial cell differentiation

PMID:15901663[3]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0045743

positive regulation of fibroblast growth factor receptor signaling pathway

PMID:11290326[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0060070

canonical Wnt signaling pathway

PMID:12490564[4]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0060070

canonical Wnt signaling pathway

PMID:16854977[6]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0060173

limb development

PMID:16575901[8]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0060219

camera-type eye photoreceptor cell differentiation

PMID:16854977[6]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0060828

regulation of canonical Wnt signaling pathway

PMID:11290326[7]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0060900

embryonic camera-type eye formation

PMID:12921742[1]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0061072

iris morphogenesis

PMID:16258938[2]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0061303

cornea development in camera-type eye

PMID:16258938[2]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0090270

regulation of fibroblast growth factor production

PMID:11290326[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0090271

positive regulation of fibroblast growth factor production

PMID:16575901[8]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Nakagawa, S et al. (2003) Identification of the laminar-inducing factor: Wnt-signal from the anterior rim induces correct laminar formation of the neural retina in vitro. Dev. Biol. 260 414-25 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Fokina, VM & Frolova, EI (2006) Expression patterns of Wnt genes during development of an anterior part of the chicken eye. Dev. Dyn. 235 496-505 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Kubo, F et al. (2005) Wnt2b inhibits differentiation of retinal progenitor cells in the absence of Notch activity by downregulating the expression of proneural genes. Development 132 2759-70 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 4.9 Kubo, F et al. (2003) Wnt2b controls retinal cell differentiation at the ciliary marginal zone. Development 130 587-98 PubMed GONUTS page
  5. 5.0 5.1 Jasoni, C et al. (1999) Analysis of chicken Wnt-13 expression demonstrates coincidence with cell division in the developing eye and is consistent with a role in induction. Dev. Dyn. 215 215-24 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 6.5 Cho, SH & Cepko, CL (2006) Wnt2b/beta-catenin-mediated canonical Wnt signaling determines the peripheral fates of the chick eye. Development 133 3167-77 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Kawakami, Y et al. (2001) WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo. Cell 104 891-900 PubMed GONUTS page
  8. 8.0 8.1 Dong, YF et al. (2006) Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor. J. Cell. Physiol. 208 77-86 PubMed GONUTS page