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CHICK:Q90998

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) TGFBR3 (ECO:0000313 with Ensembl:ENSGALP00000032713)
Protein Name(s) Transforming growth factor-beta type III receptor (ECO:0000313 with EMBL:AAA49090.1)

Uncharacterized protein (ECO:0000313 with Ensembl:ENSGALP00000032713)

External Links
UniProt Q90998
EMBL AADN03005659
L01121
PIR I50428
RefSeq NP_989670.1
UniGene Gga.804
IntAct Q90998
STRING 9031.ENSGALP00000032713
Ensembl ENSGALT00000033354
GeneID 374251
KEGG gga:374251
CTD 7049
eggNOG NOG40778
GeneTree ENSGT00530000063861
HOGENOM HOG000090193
HOVERGEN HBG057515
KO K05843
OMA FAIQTCF
OrthoDB EOG72ZCDK
PhylomeDB Q90998
TreeFam TF337375
NextBio 20813743
PRO PR:Q90998
Proteomes UP000000539
GO GO:0005783
GO:0009897
GO:0005615
GO:0070062
GO:0034673
GO:0005887
GO:0015026
GO:0005539
GO:0050431
GO:0070123
GO:0001568
GO:0060317
GO:0060038
GO:0016477
GO:0060318
GO:0009790
GO:0048566
GO:0048568
GO:0042118
GO:0001837
GO:0001654
GO:0007507
GO:0003007
GO:0060347
GO:0006955
GO:0035556
GO:0001822
GO:0001889
GO:0030324
GO:0048762
GO:0007162
GO:0022408
GO:0010633
GO:0050680
GO:0010719
GO:0007399
GO:0060021
GO:0060389
GO:0030335
GO:0010628
GO:0032354
GO:0034699
GO:0034695
GO:0007179
GO:0055010
InterPro IPR001507
IPR017977
Pfam PF00100
PRINTS PR00023
SMART SM00241
PROSITE PS00682
PS51034

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0050431

transforming growth factor beta binding

PMID:8167376[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0070123

transforming growth factor beta receptor activity, type III

PMID:8167376[1]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26342

F

Seeded From UniProt

complete

enables

GO:0050431

transforming growth factor beta binding

PMID:8167376[1]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26342

F

Seeded From UniProt

complete

enables

GO:0048185

activin binding

PMID:8167376[1]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26342

F

Seeded From UniProt

complete

involved_in

GO:0043393

regulation of protein binding

PMID:8167376[1]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26342

P

Seeded From UniProt

complete

part_of

GO:0043235

receptor complex

PMID:8167376[1]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26342

C

Seeded From UniProt

complete

involved_in

GO:0031100

animal organ regeneration

PMID:8167376[1]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26342

P

Seeded From UniProt

complete

involved_in

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

PMID:8167376[1]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26342

P

Seeded From UniProt

complete

involved_in

GO:0030511

positive regulation of transforming growth factor beta receptor signaling pathway

PMID:8167376[1]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26342

P

Seeded From UniProt

complete

enables

GO:0017134

fibroblast growth factor binding

PMID:8167376[1]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26342

F

Seeded From UniProt

complete

involved_in

GO:0016049

cell growth

PMID:8167376[1]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26342

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:8167376[1]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26342

C

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

PMID:8167376[1]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26342

F

Seeded From UniProt

complete

involved_in

GO:0007181

transforming growth factor beta receptor complex assembly

PMID:8167376[1]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26342

P

Seeded From UniProt

complete

involved_in

GO:0065003

protein-containing complex assembly

PMID:8167376[1]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26342

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:8167376[1]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26342

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:8167376[1]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26342

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:8167376[1]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26342

C

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

PMID:8167376[1]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26342

C

Seeded From UniProt

complete

enables

GO:0005160

transforming growth factor beta receptor binding

PMID:8167376[1]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26342

F

Seeded From UniProt

complete

involved_in

GO:0001666

response to hypoxia

PMID:8167376[1]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26342

P

Seeded From UniProt

complete

enables

GO:0070123

transforming growth factor beta receptor activity, type III

PMID:8167376[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

UniProtKB:Q90999

F

Seeded From UniProt

complete

contributes_to

GO:0050431

transforming growth factor beta binding

PMID:8167376[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

UniProtKB:Q90999

F

Seeded From UniProt

complete

involved_in

GO:0007507

heart development

PMID:8167376[1]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0050431

transforming growth factor beta binding

PMID:8167376[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007507

heart development

PMID:8167376[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:8167376[1]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0010227)
  • part_of:(UBERON:0006283)

Seeded From UniProt

complete

enables

GO:0050431

transforming growth factor beta binding

PMID:8167376[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

UniProtKB:P61812

F

Seeded From UniProt

complete

enables

GO:0050431

transforming growth factor beta binding

PMID:8167376[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

UniProtKB:B2R7T2

F

Seeded From UniProt

complete

enables

GO:0050431

transforming growth factor beta binding

PMID:8167376[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

UniProtKB:P61812-2

F

Seeded From UniProt

complete

enables

GO:0050431

transforming growth factor beta binding

PMID:8167376[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

UniProtKB:P01137

F

Seeded From UniProt

complete

enables

GO:0050431

transforming growth factor beta binding

PMID:8167376[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

UniProtKB:A5YM40

F

Seeded From UniProt

complete

enables

GO:0050431

transforming growth factor beta binding

PMID:8167376[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

UniProtKB:P10600

F

Seeded From UniProt

complete

enables

GO:0050431

transforming growth factor beta binding

PMID:8167376[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

UniProtKB:P10600-2

F

Seeded From UniProt

complete

enables

GO:0050431

transforming growth factor beta binding

PMID:10092230[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P01137

F

Seeded From UniProt

complete

involved_in

GO:0048762

mesenchymal cell differentiation

PMID:10092230[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048568

embryonic organ development

PMID:12704694[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048566

embryonic digestive tract development

PMID:12704694[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042118

endothelial cell activation

PMID:11500982[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030335

positive regulation of cell migration

PMID:10092230[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030324

lung development

PMID:12704694[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030324

lung development

PMID:8167376[1]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0022408

negative regulation of cell-cell adhesion

PMID:11500982[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:11500982[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

UniProtKB:P07228

P

Seeded From UniProt

complete

NOT|involved_in

GO:0010468

regulation of gene expression

PMID:11500982[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

UniProtKB:P26007

P

Seeded From UniProt

complete

NOT|involved_in

GO:0010468

regulation of gene expression

PMID:11500982[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

UniProtKB:Q9YI38

P

Seeded From UniProt

complete

NOT|involved_in

GO:0010468

regulation of gene expression

PMID:11500982[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

UniProtKB:P10039

P

Seeded From UniProt

complete

involved_in

GO:0048568

embryonic organ development

PMID:8167376[1]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

PMID:12704694[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001889

liver development

PMID:12704694[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001837

epithelial to mesenchymal transition

PMID:10092230[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001822

kidney development

PMID:12704694[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001654

eye development

PMID:8167376[1]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0070123

transforming growth factor beta receptor activity, type III

PMID:10092230[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0060317

cardiac epithelial to mesenchymal transition

PMID:10092230[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0050431

transforming growth factor beta binding

PMID:10092230[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0016477

cell migration

PMID:10092230[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:10092230[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005539

glycosaminoglycan binding

PMID:10092230[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0003007

heart morphogenesis

PMID:10092230[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001837

epithelial to mesenchymal transition

PMID:10092230[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0070123

transforming growth factor beta receptor activity, type III

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q03167
ensembl:ENSP00000212355

F

Seeded From UniProt

complete

involved_in

GO:0060389

pathway-restricted SMAD protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q03167
ensembl:ENSP00000212355

P

Seeded From UniProt

complete

involved_in

GO:0060317

cardiac epithelial to mesenchymal transition

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q03167
ensembl:ENSP00000212355

P

Seeded From UniProt

complete

involved_in

GO:0051271

negative regulation of cellular component movement

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q03167
ensembl:ENSP00000212355

P

Seeded From UniProt

complete

enables

GO:0050431

transforming growth factor beta binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q03167
ensembl:ENSP00000212355

F

Seeded From UniProt

complete

enables

GO:0046332

SMAD binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q03167
ensembl:ENSP00000212355

F

Seeded From UniProt

complete

part_of

GO:0043235

receptor complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q03167
ensembl:ENSP00000212355

C

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q03167
ensembl:ENSP00000212355

P

Seeded From UniProt

complete

involved_in

GO:0034699

response to luteinizing hormone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q03167
ensembl:ENSP00000212355

P

Seeded From UniProt

complete

involved_in

GO:0034695

response to prostaglandin E

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q03167
ensembl:ENSP00000212355

P

Seeded From UniProt

complete

part_of

GO:0034673

inhibin-betaglycan-ActRII complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q03167
ensembl:ENSP00000212355

C

Seeded From UniProt

complete

involved_in

GO:0032354

response to follicle-stimulating hormone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q03167
ensembl:ENSP00000212355

P

Seeded From UniProt

complete

enables

GO:0015026

coreceptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q03167
ensembl:ENSP00000212355

F

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q03167
ensembl:ENSP00000212355

C

Seeded From UniProt

complete

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q03167
ensembl:ENSP00000212355

P

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q03167
ensembl:ENSP00000212355

P

Seeded From UniProt

complete

enables

GO:0005114

type II transforming growth factor beta receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q03167
ensembl:ENSP00000212355

F

Seeded From UniProt

complete

enables

GO:0005024

transforming growth factor beta-activated receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q03167
ensembl:ENSP00000212355

F

Seeded From UniProt

complete

involved_in

GO:0001837

epithelial to mesenchymal transition

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q03167
ensembl:ENSP00000212355

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000040

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0060317

cardiac epithelial to mesenchymal transition

PMID:17587820[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048762

mesenchymal cell differentiation

PMID:10885742[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016477

cell migration

PMID:10885742[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007162

negative regulation of cell adhesion

PMID:17587820[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 1.19 1.20 1.21 1.22 1.23 1.24 1.25 1.26 1.27 1.28 1.29 1.30 1.31 1.32 1.33 1.34 1.35 1.36 Barnett, JV et al. (1994) Cloning and developmental expression of the chick type II and type III TGF beta receptors. Dev. Dyn. 199 12-27 PubMed GONUTS page
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 Brown, CB et al. (1999) Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart. Science 283 2080-2 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Olivey, HE et al. (2003) Expression of the type III TGFbeta receptor during chick organogenesis. Anat Rec A Discov Mol Cell Evol Biol 272 383-7 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Boyer, AS & Runyan, RB (2001) TGFbeta Type III and TGFbeta Type II receptors have distinct activities during epithelial-mesenchymal cell transformation in the embryonic heart. Dev. Dyn. 221 454-9 PubMed GONUTS page
  5. 5.0 5.1 Mercado-Pimentel, ME & Runyan, RB (2007) Multiple transforming growth factor-beta isoforms and receptors function during epithelial-mesenchymal cell transformation in the embryonic heart. Cells Tissues Organs (Print) 185 146-56 PubMed GONUTS page
  6. 6.0 6.1 Lai, YT et al. (2000) Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation. Dev. Biol. 222 1-11 PubMed GONUTS page