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CHICK:O73909

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) il-1beta (ECO:0000313 with EMBL:CAA75239.1)
Protein Name(s) IL-1 beta (ECO:0000313 with EMBL:ABD49198.1)

Interleukin-1 beta (ECO:0000313 with EMBL:ACY72339.1) Interleukin-1beta (ECO:0000313 with EMBL:CAA75239.1)

External Links
UniProt O73909
EMBL DQ393267
FJ788633
HM179638
Y15006
AJ245728
RefSeq NP_989855.1
UniGene Gga.19
PDB 2WRY
3NJ5
PDBsum 2WRY
3NJ5
STRING 9031.ENSGALP00000000737
GeneID 395196
KEGG gga:395196
CTD 3553
eggNOG NOG40099
HOGENOM HOG000246399
HOVERGEN HBG007328
KO K04519
OrthoDB EOG71P2BQ
PhylomeDB O73909
TreeFam TF300203
Reactome REACT_197463
REACT_197474
EvolutionaryTrace O73909
NextBio 20815286
PRO PR:O73909
GO GO:0005615
GO:0030141
GO:0000187
GO:0035690
GO:0071260
GO:0071407
GO:0032602
GO:0019221
GO:0035234
GO:0097192
GO:0001660
GO:0030213
GO:0006955
GO:0032611
GO:0031663
GO:0000165
GO:0070487
GO:0070164
GO:0008285
GO:2001240
GO:0010829
GO:0046627
GO:0050995
GO:0043407
GO:0030593
GO:0045766
GO:0060559
GO:0045080
GO:0031622
GO:0032725
GO:0034116
GO:0032729
GO:0045086
GO:0045410
GO:0032757
GO:0046330
GO:0050996
GO:0051044
GO:0045840
GO:0071639
GO:0035505
GO:0042346
GO:0051092
GO:0045429
GO:0032308
GO:0042102
GO:0045944
GO:0010575
GO:0043491
GO:0050796
GO:0033198
GO:0009743
GO:0030730
InterPro IPR008996
IPR003294
IPR020877
IPR000975
IPR003502
Pfam PF00340
PF02394
PRINTS PR00264
PR01357
SUPFAM SSF50353
PROSITE PS00253

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0070417

cellular response to cold

PMID:16150487[1]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009615

response to virus

PMID:18343850[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

PMID:6208795[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043400

cortisol secretion

PMID:21288573[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:H9H271

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:A3DTN5

C

Seeded From UniProt

complete

involved_in

GO:0006953

acute-phase response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:H9H271

P

Seeded From UniProt

complete

involved_in

GO:0006953

acute-phase response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:A3DTN5

P

Seeded From UniProt

complete

involved_in

GO:0032602

chemokine production

PMID:17275099[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000975

F

Seeded From UniProt

complete

enables

GO:0005149

interleukin-1 receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003296
InterPro:IPR003502

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003296

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000975
InterPro:IPR020877

C

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000975
InterPro:IPR003296
InterPro:IPR003502

P

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000975
InterPro:IPR003296
InterPro:IPR003502

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0395

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0202

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0202

C

Seeded From UniProt

complete

involved_in

GO:0051781

positive regulation of cell division

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0497

P

Seeded From UniProt

complete

involved_in

GO:0001660

fever generation

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0666

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000040

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0001660

fever generation

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000000656

P

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000000656

F

Seeded From UniProt

complete

enables

GO:0005149

interleukin-1 receptor binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000000656

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000000656

C

Seeded From UniProt

complete

involved_in

GO:0050729

positive regulation of inflammatory response

PMID:16430960[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032602

chemokine production

PMID:16430960[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032497

detection of lipopolysaccharide

PMID:16430960[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002269

leukocyte activation involved in inflammatory response

PMID:16430960[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002232

leukocyte chemotaxis involved in inflammatory response

PMID:16430960[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001660

fever generation

PMID:16430960[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

PMID:19247647[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002224

toll-like receptor signaling pathway

PMID:19247647[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019953

sexual reproduction

PMID:18539728[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Hangalapura, BN et al. (2006) Cold stress equally enhances in vivo pro-inflammatory cytokine gene expression in chicken lines divergently selected for antibody responses. Dev. Comp. Immunol. 30 503-11 PubMed GONUTS page
  2. Wu, YF et al. (2008) Characterization of interleukin-1beta mRNA expression in chicken macrophages in response to avian reovirus. J. Gen. Virol. 89 1059-68 PubMed GONUTS page
  3. Klasing, KC (1984) Effect of inflammatory agents and interleukin 1 on iron and zinc metabolism. Am. J. Physiol. 247 R901-4 PubMed GONUTS page
  4. Cheng, CS et al. (2011) Structural and functional comparison of cytokine interleukin-1 beta from chicken and human. Mol. Immunol. 48 947-55 PubMed GONUTS page
  5. Wu, YF et al. (2007) Sequence and phylogenetic analysis of interleukin (IL)-1beta-encoding genes of five avian species and structural and functional homology among these IL-1beta proteins. Vet. Immunol. Immunopathol. 116 37-46 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 6.5 Bar-Shira, E & Friedman, A (2006) Development and adaptations of innate immunity in the gastrointestinal tract of the newly hatched chick. Dev. Comp. Immunol. 30 930-41 PubMed GONUTS page
  7. 7.0 7.1 Downing, T et al. (2009) Contrasting evolution of diversity at two disease-associated chicken genes. Immunogenetics 61 303-14 PubMed GONUTS page
  8. Das, SC et al. (2009) Changes in the expression of interleukin-1beta and lipopolysaccharide-induced TNF factor in the oviduct of laying hens in response to artificial insemination. Reproduction 137 527-36 PubMed GONUTS page