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CHICK:INS

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) INS
Protein Name(s) Insulin

Insulin B chain Insulin A chain

External Links
UniProt P67970
EMBL V00416
V00418
X58993
AY438372
PIR A90796
RefSeq NP_990553.1
UniGene Gga.673
ProteinModelPortal P67970
SMR P67970
PaxDb P67970
Ensembl ENSGALT00000010581
GeneID 396145
KEGG gga:396145
CTD 3630
eggNOG NOG45999
GeneTree ENSGT00390000015440
HOGENOM HOG000261669
HOVERGEN HBG006137
InParanoid P67970
KO K04526
OMA VEQCCHN
OrthoDB EOG7TF7CG
PhylomeDB P67970
TreeFam TF332820
Reactome REACT_197049
REACT_230830
REACT_233083
REACT_234041
REACT_234309
REACT_242665
REACT_245038
REACT_251445
REACT_254277
NextBio 20816202
PRO PR:P67970
Proteomes UP000000539
GO GO:0005576
GO:0006006
GO:0043066
GO:0003407
Gene3D 1.10.100.10
InterPro IPR004825
IPR016179
IPR022353
IPR022352
Pfam PF00049
PRINTS PR00277
PR00276
SMART SM00078
SUPFAM SSF56994
PROSITE PS00262

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0010628

positive regulation of gene expression

PMID:9707581[1]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(UBERON:0000922)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:22771832[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(GO:0009267)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:16253250[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:9707581[1]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(UBERON:0000922)

Seeded From UniProt

complete

involved_in

GO:0010467

gene expression

PMID:9714146[4]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(UBERON:0003051)

Seeded From UniProt

complete

involved_in

GO:0008283

cell population proliferation

PMID:9714146[4]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(UBERON:0003051)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21325373[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004825
InterPro:IPR016179
InterPro:IPR022352

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004825
InterPro:IPR016179

C

Seeded From UniProt

complete

involved_in

GO:0003407

neural retina development

PMID:15901663[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0372

F

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0119

P

Seeded From UniProt

complete

involved_in

GO:0006006

glucose metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0313

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 de la Rosa, EJ et al. (1998) Modulation of the chaperone heat shock cognate 70 by embryonic (pro)insulin correlates with prevention of apoptosis. Proc. Natl. Acad. Sci. U.S.A. 95 9950-5 PubMed GONUTS page
  2. Song, Z et al. (2012) Fasting alters protein expression of AMP-activated protein kinase in the hypothalamus of broiler chicks (Gallus gallus domesticus). Gen. Comp. Endocrinol. 178 546-55 PubMed GONUTS page
  3. Richards, MP et al. (2006) Characterization of turkey and chicken ghrelin genes, and regulation of ghrelin and ghrelin receptor mRNA levels in broiler chickens. Gen. Comp. Endocrinol. 145 298-310 PubMed GONUTS page
  4. 4.0 4.1 León, Y et al. (1998) Induction of cell growth by insulin and insulin-like growth factor-I is associated with Jun expression in the otic vesicle. J. Comp. Neurol. 398 323-32 PubMed GONUTS page
  5. Song, ZG et al. (2011) Dexamethasone alters the expression of genes related to the growth of skeletal muscle in chickens (Gallus gallus domesticus). J. Mol. Endocrinol. 46 217-25 PubMed GONUTS page
  6. Kubo, F et al. (2005) Wnt2b inhibits differentiation of retinal progenitor cells in the absence of Notch activity by downregulating the expression of proneural genes. Development 132 2759-70 PubMed GONUTS page