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CHICK:IL10

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) IL10 (ECO:0000312 with EMBL:CAF21727.1)
Protein Name(s) Interleukin-10

IL-10

External Links
UniProt Q6A2H4
EMBL AJ621614
AJ621254
AY647438
RefSeq NP_001004414.2
UniGene Gga.46641
ProteinModelPortal Q6A2H4
PaxDb Q6A2H4
PRIDE Q6A2H4
Ensembl ENSGALT00000001312
GeneID 428264
KEGG gga:428264
CTD 3586
eggNOG NOG43085
GeneTree ENSGT00510000048535
HOGENOM HOG000072692
HOVERGEN HBG004110
InParanoid Q6A2H4
KO K05443
OMA PHMLREL
PhylomeDB Q6A2H4
NextBio 20829305
PRO PR:Q6A2H4
Proteomes UP000000539
GO GO:0005576
GO:0005615
GO:0042742
GO:0042832
GO:0006955
GO:0006954
GO:0030889
GO:0002875
GO:0002740
GO:0044130
GO:0045077
GO:0032695
GO:0032715
GO:0051045
GO:0030886
GO:0045019
GO:0002826
GO:0032720
GO:0002904
GO:0050715
GO:0045348
GO:0051091
GO:0045944
GO:0032800
GO:0051384
GO:0002237
Gene3D 1.20.1250.10
InterPro IPR009079
IPR012351
IPR000098
IPR020443
PANTHER PTHR11585
Pfam PF00726
PRINTS PR01294
SMART SM00188
SUPFAM SSF47266

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0045077

negative regulation of interferon-gamma biosynthetic process

PMID:15294985[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045019

negative regulation of nitric oxide biosynthetic process

PMID:15294985[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042832

defense response to protozoan

PMID:16996141[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042832

defense response to protozoan

PMID:17045659[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042832

defense response to protozoan

PMID:15294985[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:15294985[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0002826

negative regulation of T-helper 1 type immune response

PMID:15294985[1]

ECO:0000305

curator inference used in manual assertion

GO:0045077

P

Seeded From UniProt

complete

involved_in

GO:2000352

negative regulation of endothelial cell apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18893
ensembl:ENSMUSP00000016673

P

Seeded From UniProt

complete

involved_in

GO:1904706

negative regulation of vascular smooth muscle cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18893
ensembl:ENSMUSP00000016673

P

Seeded From UniProt

complete

involved_in

GO:1903672

positive regulation of sprouting angiogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18893
ensembl:ENSMUSP00000016673

P

Seeded From UniProt

complete

involved_in

GO:1903208

negative regulation of hydrogen peroxide-induced neuron death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18893
ensembl:ENSMUSP00000016673

P

Seeded From UniProt

complete

involved_in

GO:1903034

regulation of response to wounding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18893
ensembl:ENSMUSP00000016673

P

Seeded From UniProt

complete

involved_in

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18893
ensembl:ENSMUSP00000016673

P

Seeded From UniProt

complete

involved_in

GO:0071222

cellular response to lipopolysaccharide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18893
ensembl:ENSMUSP00000016673

P

Seeded From UniProt

complete

involved_in

GO:0050728

negative regulation of inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18893
ensembl:ENSMUSP00000016673

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18893
ensembl:ENSMUSP00000016673

P

Seeded From UniProt

complete

involved_in

GO:0045787

positive regulation of cell cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18893
ensembl:ENSMUSP00000016673

P

Seeded From UniProt

complete

involved_in

GO:0045348

positive regulation of MHC class II biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18893
ensembl:ENSMUSP00000016673

P

Seeded From UniProt

complete

involved_in

GO:0044130

negative regulation of growth of symbiont in host

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18893
ensembl:ENSMUSP00000016673

P

Seeded From UniProt

complete

involved_in

GO:0042832

defense response to protozoan

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18893
ensembl:ENSMUSP00000016673

P

Seeded From UniProt

complete

involved_in

GO:0042742

defense response to bacterium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18893
ensembl:ENSMUSP00000016673

P

Seeded From UniProt

complete

involved_in

GO:0035729

cellular response to hepatocyte growth factor stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18893
ensembl:ENSMUSP00000016673

P

Seeded From UniProt

complete

involved_in

GO:0034115

negative regulation of heterotypic cell-cell adhesion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18893
ensembl:ENSMUSP00000016673

P

Seeded From UniProt

complete

involved_in

GO:0032720

negative regulation of tumor necrosis factor production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18893
ensembl:ENSMUSP00000016673

P

Seeded From UniProt

complete

involved_in

GO:0032695

negative regulation of interleukin-12 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18893
ensembl:ENSMUSP00000016673

P

Seeded From UniProt

complete

involved_in

GO:0032689

negative regulation of interferon-gamma production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18893
ensembl:ENSMUSP00000016673

P

Seeded From UniProt

complete

involved_in

GO:0030886

negative regulation of myeloid dendritic cell activation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18893
ensembl:ENSMUSP00000016673

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18893
ensembl:ENSMUSP00000016673

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18893
ensembl:ENSMUSP00000016673

C

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18893
ensembl:ENSMUSP00000016673

F

Seeded From UniProt

complete

involved_in

GO:0002875

negative regulation of chronic inflammatory response to antigenic stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18893
ensembl:ENSMUSP00000016673

P

Seeded From UniProt

complete

involved_in

GO:0001938

positive regulation of endothelial cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18893
ensembl:ENSMUSP00000016673

P

Seeded From UniProt

complete

involved_in

GO:0060302

negative regulation of cytokine activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22301
ensembl:ENSP00000412237

P

Seeded From UniProt

complete

involved_in

GO:0051384

response to glucocorticoid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22301
ensembl:ENSP00000412237

P

Seeded From UniProt

complete

involved_in

GO:0051091

positive regulation of DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22301
ensembl:ENSP00000412237

P

Seeded From UniProt

complete

involved_in

GO:0051045

negative regulation of membrane protein ectodomain proteolysis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22301
ensembl:ENSP00000412237

P

Seeded From UniProt

complete

involved_in

GO:0050715

positive regulation of cytokine secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22301
ensembl:ENSP00000412237

P

Seeded From UniProt

complete

enables

GO:0046983

protein dimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22301
ensembl:ENSP00000412237

F

Seeded From UniProt

complete

involved_in

GO:0046427

positive regulation of receptor signaling pathway via JAK-STAT

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22301
ensembl:ENSP00000412237

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22301
ensembl:ENSP00000412237

P

Seeded From UniProt

complete

involved_in

GO:0045347

negative regulation of MHC class II biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22301
ensembl:ENSP00000412237

P

Seeded From UniProt

complete

involved_in

GO:0032800

receptor biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22301
ensembl:ENSP00000412237

P

Seeded From UniProt

complete

involved_in

GO:0032715

negative regulation of interleukin-6 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22301
ensembl:ENSP00000412237

P

Seeded From UniProt

complete

involved_in

GO:0030889

negative regulation of B cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22301
ensembl:ENSP00000412237

P

Seeded From UniProt

complete

involved_in

GO:0010507

negative regulation of autophagy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22301
ensembl:ENSP00000412237

P

Seeded From UniProt

complete

involved_in

GO:0010468

regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22301
ensembl:ENSP00000412237

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22301
ensembl:ENSP00000412237

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22301
ensembl:ENSP00000412237

C

Seeded From UniProt

complete

involved_in

GO:0002904

positive regulation of B cell apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22301
ensembl:ENSP00000412237

P

Seeded From UniProt

complete

involved_in

GO:0002740

negative regulation of cytokine secretion involved in immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22301
ensembl:ENSP00000412237

P

Seeded From UniProt

complete

involved_in

GO:0002237

response to molecule of bacterial origin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22301
ensembl:ENSP00000412237

P

Seeded From UniProt

complete

involved_in

GO:0001818

negative regulation of cytokine production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22301
ensembl:ENSP00000412237

P

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000098

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000098

C

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000098

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

C

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Rothwell, L et al. (2004) Cloning and characterization of chicken IL-10 and its role in the immune response to Eimeria maxima. J. Immunol. 173 2675-82 PubMed GONUTS page
  2. Hong, YH et al. (2006) Analysis of chicken cytokine and chemokine gene expression following Eimeria acervulina and Eimeria tenella infections. Vet. Immunol. Immunopathol. 114 209-23 PubMed GONUTS page
  3. Hong, YH et al. (2006) Changes in immune-related gene expression and intestinal lymphocyte subpopulations following Eimeria maxima infection of chickens. Vet. Immunol. Immunopathol. 114 259-72 PubMed GONUTS page