CHICK:BCL6

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0000060	protein import into nucleus, translocation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000384371	P
	GO:0000060	protein import into nucleus, translocation	PMID:11821949^[1]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41182	P
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	P
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000384371	P
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:12817026^[2]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	P
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:15577913^[3]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41182	P
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:15611242^[4]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	P
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:9110977^[5]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	P
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:9632807^[6]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	P
	GO:0000902	cell morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	P
	GO:0000902	cell morphogenesis	PMID:15860730^[7]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	P
	GO:0001953	negative regulation of cell-matrix adhesion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	P
	GO:0001953	negative regulation of cell-matrix adhesion	PMID:15860730^[7]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	P
	GO:0002467	germinal center formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	P
	GO:0002467	germinal center formation	PMID:12354385^[8]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	P
	GO:0002829	negative regulation of type 2 immune response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	P
	GO:0002829	negative regulation of type 2 immune response	PMID:10438949^[9]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	P
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013087	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003677	DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	F
	GO:0003682	chromatin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	F
	GO:0003682	chromatin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000384371	F
	GO:0003682	chromatin binding	PMID:12817026^[2]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000384371	F
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007087	C
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015880	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000384371	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:10898795^[10]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41182	C
	GO:0005634	nucleus	PMID:9632807^[6]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	C
	GO:0005657	replication fork	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000384371	C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006351	transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000384371	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006974	response to DNA damage stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000384371	P
	GO:0006974	response to DNA damage stimulus	PMID:15577913^[3]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41182	P
	GO:0007266	Rho protein signal transduction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	P
	GO:0007266	Rho protein signal transduction	PMID:15860730^[7]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	P
	GO:0007283	spermatogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	P
	GO:0007283	spermatogenesis	PMID:11092811^[11]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	P
	GO:0008104	protein localization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	P
	GO:0008104	protein localization	PMID:15860730^[7]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	P
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007087	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015880	F
	GO:0008285	negative regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	P
	GO:0008285	negative regulation of cell proliferation	PMID:15507530^[12]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	P
	GO:0030036	actin cytoskeleton organization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	P
	GO:0030036	actin cytoskeleton organization	PMID:15860730^[7]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	P
	GO:0030183	B cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	P
	GO:0030183	B cell differentiation	PMID:14647274^[13]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	P
	GO:0030308	negative regulation of cell growth	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000384371	P
	GO:0030308	negative regulation of cell growth	PMID:10490843^[14]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41182	P
	GO:0030890	positive regulation of B cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	P
	GO:0030890	positive regulation of B cell proliferation	PMID:9171827^[15]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	P
	GO:0031490	chromatin DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	F
	GO:0032319	regulation of Rho GTPase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	P
	GO:0032319	regulation of Rho GTPase activity	PMID:15860730^[7]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	P
	GO:0032764	negative regulation of mast cell cytokine production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	P
	GO:0032764	negative regulation of mast cell cytokine production	PMID:15950739^[16]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	P
	GO:0035024	negative regulation of Rho protein signal transduction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	P
	GO:0035024	negative regulation of Rho protein signal transduction	PMID:15860730^[7]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	P
	GO:0042092	type 2 immune response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	P
	GO:0042127	regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	P
	GO:0043065	positive regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000384371	P
	GO:0043065	positive regulation of apoptosis	PMID:10490843^[14]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41182	P
	GO:0043066	negative regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	P
	GO:0043066	negative regulation of apoptosis	PMID:11092811^[11]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	P
	GO:0043380	regulation of memory T cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	P
	GO:0043380	regulation of memory T cell differentiation	PMID:15240675^[17]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	P
	GO:0043565	sequence-specific DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	F
	GO:0043565	sequence-specific DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000384371	F
	GO:0043565	sequence-specific DNA binding	PMID:15577913^[3]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41182	F
	GO:0043565	sequence-specific DNA binding	PMID:15659391^[18]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	F
	GO:0045596	negative regulation of cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	P
	GO:0045629	negative regulation of T-helper 2 cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	P
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:10490661^[19]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	P
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:15577913^[3]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41182	P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0048294	negative regulation of isotype switching to IgE isotypes	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	P
	GO:0048294	negative regulation of isotype switching to IgE isotypes	PMID:10490661^[19]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	P
	GO:0048821	erythrocyte development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	P
	GO:0048821	erythrocyte development	PMID:15661395^[20]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	P
	GO:0050727	regulation of inflammatory response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	P
	GO:0050727	regulation of inflammatory response	PMID:9110977^[5]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	P
	GO:0051272	positive regulation of cellular component movement	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023151	P
	GO:0051272	positive regulation of cellular component movement	PMID:15860730^[7]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41183	P
colocalizes_with	GO:0005657	replication fork	PMID:10490843^[14]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P41182	C
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Ueda C et al. (2002) The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma. Oncogene 21: 368-76 PubMed GONUTS page
↑ ^2.0 ^2.1 Takeda N et al. (2003) Bcl6 is a transcriptional repressor for the IL-18 gene. J Immunol 171: 426-31 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Phan RT & Dalla-Favera R (2004) The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells. Nature 432: 635-9 PubMed GONUTS page
↑ Li Z et al. (2005) BCL-6 negatively regulates expression of the NF-kappaB1 p105/p50 subunit. J Immunol 174: 205-14 PubMed GONUTS page
↑ ^5.0 ^5.1 Dent AL et al. (1997) Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 276: 589-92 PubMed GONUTS page
↑ ^6.0 ^6.1 Okabe S et al. (1998) BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor. Mol Cell Biol 18: 4235-44 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Pixley FJ et al. (2005) BCL6 suppresses RhoA activity to alter macrophage morphology and motility. J Cell Sci 118: 1873-83 PubMed GONUTS page
↑ Toyama H et al. (2002) Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells. Immunity 17: 329-39 PubMed GONUTS page
↑ Dent AL et al. (1999) BCL-6-deficient mice reveal an IL-4-independent, STAT6-dependent pathway that controls susceptibility to infection by Leishmania major. J Immunol 163: 2098-103 PubMed GONUTS page
↑ Huynh KD et al. (2000) BCoR, a novel corepressor involved in BCL-6 repression. Genes Dev 14: 1810-23 PubMed GONUTS page
↑ ^11.0 ^11.1 Kojima S et al. (2001) Testicular germ cell apoptosis in Bcl6-deficient mice. Development 128: 57-65 PubMed GONUTS page
↑ Yu RY et al. (2005) BCL-6 negatively regulates macrophage proliferation by suppressing autocrine IL-6 production. Blood 105: 1777-84 PubMed GONUTS page
↑ Hasbold J et al. (2004) Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation. Nat Immunol 5: 55-63 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Albagli O et al. (1999) Overexpressed BCL6 (LAZ3) oncoprotein triggers apoptosis, delays S phase progression and associates with replication foci. Oncogene 18: 5063-75 PubMed GONUTS page
↑ Ye BH et al. (1997) The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat Genet 16: 161-70 PubMed GONUTS page
↑ Ohtsuka Y et al. (2005) Bcl6 regulates Th2 type cytokine productions by mast cells activated by FcepsilonRI/IgE cross-linking. Mol Immunol 42: 1453-9 PubMed GONUTS page
↑ Ichii H et al. (2004) Bcl6 acts as an amplifier for the generation and proliferative capacity of central memory CD8+ T cells. J Immunol 173: 883-91 PubMed GONUTS page
↑ Harris MB et al. (2005) Repression of an interleukin-4-responsive promoter requires cooperative BCL-6 function. J Biol Chem 280: 13114-21 PubMed GONUTS page
↑ ^19.0 ^19.1 Harris MB et al. (1999) Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching. Mol Cell Biol 19: 7264-75 PubMed GONUTS page
↑ Asari S et al. (2005) Abnormal erythroid differentiation in neonatal bcl-6-deficient mice. Exp Hematol 33: 26-34 PubMed GONUTS page

[PMID:11821949-0] Ueda C et al. (2002) The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma. Oncogene 21: 368-76 PubMed GONUTS page

[PMID:12817026-1] 2.0 ^2.1 Takeda N et al. (2003) Bcl6 is a transcriptional repressor for the IL-18 gene. J Immunol 171: 426-31 PubMed GONUTS page

[PMID:15577913-2] 3.0 ^3.1 ^3.2 ^3.3 Phan RT & Dalla-Favera R (2004) The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells. Nature 432: 635-9 PubMed GONUTS page

[PMID:15611242-3] Li Z et al. (2005) BCL-6 negatively regulates expression of the NF-kappaB1 p105/p50 subunit. J Immunol 174: 205-14 PubMed GONUTS page

[PMID:9110977-4] 5.0 ^5.1 Dent AL et al. (1997) Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 276: 589-92 PubMed GONUTS page

[PMID:9632807-5] 6.0 ^6.1 Okabe S et al. (1998) BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor. Mol Cell Biol 18: 4235-44 PubMed GONUTS page

[PMID:15860730-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Pixley FJ et al. (2005) BCL6 suppresses RhoA activity to alter macrophage morphology and motility. J Cell Sci 118: 1873-83 PubMed GONUTS page

[PMID:12354385-7] Toyama H et al. (2002) Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells. Immunity 17: 329-39 PubMed GONUTS page

[PMID:10438949-8] Dent AL et al. (1999) BCL-6-deficient mice reveal an IL-4-independent, STAT6-dependent pathway that controls susceptibility to infection by Leishmania major. J Immunol 163: 2098-103 PubMed GONUTS page

[PMID:10898795-9] Huynh KD et al. (2000) BCoR, a novel corepressor involved in BCL-6 repression. Genes Dev 14: 1810-23 PubMed GONUTS page

[PMID:11092811-10] 11.0 ^11.1 Kojima S et al. (2001) Testicular germ cell apoptosis in Bcl6-deficient mice. Development 128: 57-65 PubMed GONUTS page

[PMID:15507530-11] Yu RY et al. (2005) BCL-6 negatively regulates macrophage proliferation by suppressing autocrine IL-6 production. Blood 105: 1777-84 PubMed GONUTS page

[PMID:14647274-12] Hasbold J et al. (2004) Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation. Nat Immunol 5: 55-63 PubMed GONUTS page

[PMID:10490843-13] 14.0 ^14.1 ^14.2 Albagli O et al. (1999) Overexpressed BCL6 (LAZ3) oncoprotein triggers apoptosis, delays S phase progression and associates with replication foci. Oncogene 18: 5063-75 PubMed GONUTS page

[PMID:9171827-14] Ye BH et al. (1997) The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat Genet 16: 161-70 PubMed GONUTS page

[PMID:15950739-15] Ohtsuka Y et al. (2005) Bcl6 regulates Th2 type cytokine productions by mast cells activated by FcepsilonRI/IgE cross-linking. Mol Immunol 42: 1453-9 PubMed GONUTS page

[PMID:15240675-16] Ichii H et al. (2004) Bcl6 acts as an amplifier for the generation and proliferative capacity of central memory CD8+ T cells. J Immunol 173: 883-91 PubMed GONUTS page

[PMID:15659391-17] Harris MB et al. (2005) Repression of an interleukin-4-responsive promoter requires cooperative BCL-6 function. J Biol Chem 280: 13114-21 PubMed GONUTS page

[PMID:10490661-18] 19.0 ^19.1 Harris MB et al. (1999) Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching. Mol Cell Biol 19: 7264-75 PubMed GONUTS page

[PMID:15661395-19] Asari S et al. (2005) Abnormal erythroid differentiation in neonatal bcl-6-deficient mice. Exp Hematol 33: 26-34 PubMed GONUTS page

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Species (Taxon ID)	Gallus gallus (Chicken). (taxon:9031)
Gene Name(s)	BCL6
Protein Name(s)	B-cell lymphoma 6 protein homolog
External Links
UniProt Identifier	BCL6_CHICK
UniProt Accessions	Q5ZM39,
EMBL	AJ719545,
RefSeq	NP_001012948.1,
Pfam	PF00651, PF00096,

CHICK:BCL6

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