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CHICK:AVR2B

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) ACVR2B
Protein Name(s) Activin receptor type-2B

Activin receptor type IIB ACTR-IIB

External Links
UniProt Q90670
EMBL U31223
RefSeq NP_989648.1
UniGene Gga.764
ProteinModelPortal Q90670
SMR Q90670
STRING 9031.ENSGALP00000030643
PaxDb Q90670
GeneID 374213
KEGG gga:374213
CTD 93
eggNOG COG0515
HOGENOM HOG000231495
HOVERGEN HBG054502
InParanoid Q90670
KO K13596
PhylomeDB Q90670
NextBio 20813717
PRO PR:Q90670
Proteomes UP000000539
GO GO:0016021
GO:0005524
GO:0046872
GO:0004702
GO:0004675
InterPro IPR011009
IPR000719
IPR008271
IPR000472
IPR000333
PANTHER PTHR23255
Pfam PF01064
PF00069
PRINTS PR00653
SUPFAM SSF56112
PROSITE PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0009798

axis specification

PMID:7589799[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0048185

activin binding

PMID:7589799[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0045178

basal part of cell

PMID:20071511[2]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0002295)
  • part_of:(CL:0000202)|part_of:(UBERON:0002295)
  • part_of:(CL:0005014)

Seeded From UniProt

complete

involved_in

GO:0008283

cell population proliferation

PMID:20071511[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

acts_on_population_of:(CL:0005014)

Seeded From UniProt

complete

involved_in

GO:0032924

activin receptor signaling pathway

PMID:20071511[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061550

cranial ganglion development

PMID:25660516[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0002058)

Seeded From UniProt

complete

involved_in

GO:0043525

positive regulation of neuron apoptotic process

PMID:25660516[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0002058)

Seeded From UniProt

complete

involved_in

GO:0048333

mesodermal cell differentiation

PMID:7589799[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

results_in_formation_of:(UBERON:0001135)|results_in_formation_of:(UBERON:0001134)|results_in_formation_of:(UBERON:0001133)|results_in_formation_of:(UBERON:0002328)|results_in_formation_of:(UBERON:0003062)

Seeded From UniProt

complete

enables

GO:0048185

activin binding

PMID:7589799[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1901389

negative regulation of transforming growth factor beta activation

DOI:10.1016/j.procbio.2011.10.027

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0048185

activin binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:102806
MGI:MGI:87912
PANTHER:PTN001147373
RGD:2028
RGD:70911
UniProtKB:A0A0B4KG59
UniProtKB:F1NCI7
UniProtKB:P27037
UniProtKB:Q90669
UniProtKB:Q90670

F

Seeded From UniProt

complete

enables

GO:0048185

activin binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:102806
MGI:MGI:87912
PANTHER:PTN000583717
RGD:2028
RGD:70911
UniProtKB:F1NCI7
UniProtKB:P27037
UniProtKB:Q90669
UniProtKB:Q90670

F

Seeded From UniProt

complete

part_of

GO:0048179

activin receptor complex

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001147373
UniProtKB:A0A0B4KG59

C

Seeded From UniProt

complete

enables

GO:0046332

SMAD binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98728
MGI:MGI:98729
PANTHER:PTN000583675
RGD:621789
UniProtKB:O00238
UniProtKB:P36894
UniProtKB:P36896
UniProtKB:P36897
UniProtKB:P37023
UniProtKB:P37173
UniProtKB:Q04771

F

Seeded From UniProt

complete

part_of

GO:0043235

receptor complex

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000583675
UniProtKB:P27037
UniProtKB:P36896
UniProtKB:P36897
UniProtKB:P37173
UniProtKB:Q13705

C

Seeded From UniProt

complete

enables

GO:0034713

type I transforming growth factor beta receptor binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001147373
UniProtKB:P37173
UniProtKB:Q90999

F

Seeded From UniProt

complete

involved_in

GO:0032924

activin receptor signaling pathway

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001147373
UniProtKB:A0A0B4KG59
UniProtKB:F1NCI7
UniProtKB:P27037
UniProtKB:Q13705
UniProtKB:Q90669
UniProtKB:Q90670

P

Seeded From UniProt

complete

enables

GO:0019838

growth factor binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:102806
MGI:MGI:87911
MGI:MGI:87912
PANTHER:PTN000583675
RGD:71082
UniProtKB:P36896
UniProtKB:P36897
UniProtKB:Q13705
UniProtKB:Q8NER5

F

Seeded From UniProt

complete

involved_in

GO:0007389

pattern specification process

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1338938
MGI:MGI:87912
PANTHER:PTN000583675

P

Seeded From UniProt

complete

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003716
MGI:MGI:1338946
MGI:MGI:87911
MGI:MGI:98728
MGI:MGI:98729
PANTHER:PTN000583675
RGD:3852
RGD:620200
RGD:69651
RGD:70964
UniProtKB:A0A0B4KG59
UniProtKB:P36897
UniProtKB:P37023
UniProtKB:P37173
UniProtKB:Q04771
UniProtKB:Q06900
UniProtKB:Q90ZK6

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:87911
PANTHER:PTN000583675
RGD:69651
RGD:70964
UniProtKB:P36896
UniProtKB:P37023
UniProtKB:Q04771
UniProtKB:Q13873

C

Seeded From UniProt

complete

enables

GO:0005026

transforming growth factor beta receptor activity, type II

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001147373
RGD:69651

F

Seeded From UniProt

complete

enables

GO:0005024

transforming growth factor beta-activated receptor activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98728
MGI:MGI:98729
PANTHER:PTN000583675
UniProtKB:A0A0B4KG59
UniProtKB:P36897
UniProtKB:P37023
UniProtKB:P37173
ZFIN:ZDB-GENE-070618-1

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0004675

transmembrane receptor protein serine/threonine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000333
InterPro:IPR000472

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000333
InterPro:IPR000719

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

P

Seeded From UniProt

complete

involved_in

GO:0007178

transmembrane receptor protein serine/threonine kinase signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000333

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000333
InterPro:IPR000472

C

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Stern, CD et al. (1995) Activin and its receptors during gastrulation and the later phases of mesoderm development in the chick embryo. Dev. Biol. 172 192-205 PubMed GONUTS page
  2. 2.0 2.1 2.2 McCullar, JS et al. (2010) Activin potentiates proliferation in mature avian auditory sensory epithelium. J. Neurosci. 30 478-90 PubMed GONUTS page
  3. 3.0 3.1 Koszinowski, S et al. (2015) Signaling via the transcriptionally regulated activin receptor 2B is a novel mediator of neuronal cell death during chicken ciliary ganglion development. Int. J. Dev. Neurosci. 41 98-104 PubMed GONUTS page
  4. 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page