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CAEEL:PEN2
Contents |
| Species (Taxon ID) | Caenorhabditis elegans. (taxon:6239) | |
| Gene Name(s) | pen-2 | |
| Protein Name(s) |
| |
| External Links | ||
| UniProt Identifier | PEN2_CAEEL | |
| UniProt Accessions | Q9U357, | |
| EMBL | Z81134, | |
| PIR | T25417, | |
| RefSeq | NP_499459.1, | |
| IntAct | Q9U357, | |
| Pfam | PF10251, | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0048598 |
embryonic morphogenesis |
IMP: Inferred from Mutant Phenotype |
|
P |
||||
| GO:0000139 |
Golgi membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0134 |
C |
||||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0007281 |
germ cell development |
IGI: Inferred from Genetic Interaction |
|
P |
||||
| GO:0007219 |
Notch signaling pathway |
IMP: Inferred from Mutant Phenotype |
P |
Figure 2. Embryos deficient in pen-2 do not develop the anterior pharynx and arrest development with severe morphological defects. This phenotype is indistinguishable from presenilin deficiency, suggesting that pen-2 plays a role in Notch signaling. |
complete | |||
| GO:0005794 |
Golgi apparatus |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0045165 |
cell fate commitment |
IGI: Inferred from Genetic Interaction |
|
P |
||||
| GO:0005789 |
endoplasmic reticulum membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0097 |
C |
||||
| GO:0005783 |
endoplasmic reticulum |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0007219 |
Notch signaling pathway |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0009792 |
embryo development ending in birth or egg hatching |
IMP: Inferred from Mutant Phenotype |
|
P |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0016020 |
membrane |
IDA: Inferred from Direct Assay |
C |
Figure 3. pen-2 DNA was hybridized with GFP. The fluorescent signal coming from the cytosol was sporadic, but the intracellular membranes showed a constant signal, suggesting that pen-2 is localized to internal membranes. |
complete | |||
| GO:0060465 |
pharynx development |
IMP: Inferred from Mutant Phenotype |
P |
Figure 2 A-F. C. elegans embryos deficient in pen-2 fail to develop the anterior pharynx. |
complete | |||
| GO:0000139 |
Golgi membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0134 |
C |
||||
| GO:0005783 |
endoplasmic reticulum |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0005789 |
endoplasmic reticulum membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0097 |
C |
||||
| GO:0005794 |
Golgi apparatus |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0007219 |
Notch signaling pathway |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0007219 |
Notch signaling pathway |
IMP: Inferred from Mutant Phenotype |
WB:WBVar00145189 |
P |
||||
| GO:0007281 |
germ cell development |
IGI: Inferred from Genetic Interaction |
WB:WBGene00004769 |
P |
||||
| GO:0009792 |
embryo development ending in birth or egg hatching |
IMP: Inferred from Mutant Phenotype |
WB:WBVar00145189 |
P |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0016020 |
membrane |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0045165 |
cell fate commitment |
IGI: Inferred from Genetic Interaction |
WB:WBGene00004769 |
P |
||||
| GO:0048598 |
embryonic morphogenesis |
IMP: Inferred from Mutant Phenotype |
WB:WBVar00145189 |
P |
||||
| GO:0060465 |
pharynx development |
IMP: Inferred from Mutant Phenotype |
WB:WBVar00145189 |
P |
| |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 Francis R et al. (2002) aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev Cell 3: 85-97 PubMed GONUTS page
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