BOVIN:ADA

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Species (Taxon ID)	Bos taurus (Bovine). (taxon:9913)
Gene Name(s)	ADA
Protein Name(s)	Adenosine deaminase Adenosine aminohydrolase
External Links
UniProt Identifier	ADA_BOVIN
UniProt Accessions	P56658, Q9MYY1,
EMBL	AF280603,
RefSeq	NP_776312.1,
PDB	1KRM, 1NDV, 1NDW, 1NDY, 1NDZ, 1O5R, 1QXL, 1UML, 1V79, 1V7A, 1VFL, 1W1I, 1WXY, 1WXZ, 2BGN, 2E1W, 2Z7G,
Pfam	PF00962,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005488	binding	PMID:3486673^[1]	IDA: Inferred from Direct Assay	CHEBI:27834	F	Deoxycoformycin	complete
	GO:0004000	adenosine deaminase activity	PMID:5335916^[2]	IDA: Inferred from Direct Assay		F	ADA was purified and assayed for adenosine deaminase activity (Figure 1).	complete
	GO:0001666	response to hypoxia	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000361965	P
	GO:0001701	in utero embryonic development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0001829	trophectodermal cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0001889	liver development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0001890	placenta development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0002314	germinal center B cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0002636	positive regulation of germinal center formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0002686	negative regulation of leukocyte migration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0002906	negative regulation of mature B cell apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0004000	adenosine deaminase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006330	F
	GO:0004000	adenosine deaminase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:3.5.4.4	F
	GO:0004000	adenosine deaminase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	F
	GO:0004000	adenosine deaminase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000361965	F
	GO:0004000	adenosine deaminase activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P03958	F
	GO:0004000	adenosine deaminase activity	GO_REF:0000033		PANTHER:PTHR11409_AN1	F
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000361965	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005764	lysosome	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000361965	C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000361965	C
	GO:0005829	cytosol	GO_REF:0000033		PANTHER:PTHR11409_AN1	C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000361965	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0006154	adenosine catabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0006154	adenosine catabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000361965	P
	GO:0006154	adenosine catabolic process	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P03958	P
	GO:0006154	adenosine catabolic process	GO_REF:0000033		PANTHER:PTHR11409_AN1	P
	GO:0006157	deoxyadenosine catabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0007155	cell adhesion	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0130	P
	GO:0008270	zinc ion binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	F
	GO:0008270	zinc ion binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000361965	F
	GO:0008270	zinc ion binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P03958	F
	GO:0009117	nucleotide metabolic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0546	P
	GO:0009168	purine ribonucleoside monophosphate biosynthetic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001365	P
	GO:0009168	purine ribonucleoside monophosphate biosynthetic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006330	P
	GO:0009168	purine ribonucleoside monophosphate biosynthetic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006650	P
	GO:0009897	external side of plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000361965	C
	GO:0009897	external side of plasma membrane	GO_REF:0000033		PANTHER:PTHR11409_AN128	C
	GO:0009986	cell surface	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000361965	C
	GO:0010460	positive regulation of heart rate	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016020	membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000361965	C
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0019239	deaminase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001365	F
	GO:0019239	deaminase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006650	F
	GO:0030054	cell junction	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0965	C
	GO:0030054	cell junction	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0038	C
	GO:0030324	lung development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0030890	positive regulation of B cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0031410	cytoplasmic vesicle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0968	C
	GO:0032261	purine nucleotide salvage	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000361965	P
	GO:0033089	positive regulation of T cell differentiation in thymus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0033632	regulation of cell-cell adhesion mediated by integrin	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000361965	P
	GO:0042110	T cell activation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000361965	P
	GO:0042110	T cell activation	GO_REF:0000033		PANTHER:PTHR11409_AN128	P
	GO:0043066	negative regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0043103	hypoxanthine salvage	GO_REF:0000033		PANTHER:PTHR11409_AN1	P
	GO:0045580	regulation of T cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0045582	positive regulation of T cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0045987	positive regulation of smooth muscle contraction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0046061	dATP catabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0046101	hypoxanthine biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0046103	inosine biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0046103	inosine biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000361965	P
	GO:0046103	inosine biosynthetic process	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P03958	P
	GO:0046103	inosine biosynthetic process	GO_REF:0000033		PANTHER:PTHR11409_AN1	P
	GO:0046111	xanthine biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0046638	positive regulation of alpha-beta T cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0048286	lung alveolus development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0048541	Peyer's patch development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0048566	embryonic digestive tract development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0050728	negative regulation of inflammatory response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0050850	positive regulation of calcium-mediated signaling	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0050862	positive regulation of T cell receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0050870	positive regulation of T cell activation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0060169	negative regulation of adenosine receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000361965	P
	GO:0060169	negative regulation of adenosine receptor signaling pathway	GO_REF:0000033		PANTHER:PTHR11409_AN128	P
	GO:0060205	cytoplasmic membrane-bounded vesicle lumen	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0325	C
	GO:0060407	negative regulation of penile erection	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0070244	negative regulation of thymocyte apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
	GO:0070256	negative regulation of mucus secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000017841	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Frick L et al. (1986) Transition-state stabilization by adenosine deaminase: structural studies of its inhibitory complex with deoxycoformycin. Biochemistry 25: 1616-21 PubMed GONUTS page
↑ Wolfenden R et al. (1967) Substrate binding by adenosine deaminase. Specificity, pH dependence, and competition by mercurials. J Biol Chem 242: 977-83 PubMed GONUTS page

[PMID:3486673-0] Frick L et al. (1986) Transition-state stabilization by adenosine deaminase: structural studies of its inhibitory complex with deoxycoformycin. Biochemistry 25: 1616-21 PubMed GONUTS page

[PMID:5335916-1] Wolfenden R et al. (1967) Substrate binding by adenosine deaminase. Specificity, pH dependence, and competition by mercurials. J Biol Chem 242: 977-83 PubMed GONUTS page

[1]

[2]

BOVIN:ADA

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