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BACSU:ERA

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Contents

Species (Taxon ID) Bacillus subtilis. ([1])
Gene Name(s) era (synonyms: bex, yqfH)
Protein Name(s) GTPase Era

Bex protein

External Links
EMBL U18532
D84432
AL009126
X17430
PIR B69593
RefSeq NP_390407.1
ProteinModelPortal P42182
SMR P42182
EnsemblBacteria EBBACT00000003334
GeneID 937871
GenomeReviews AL009126_GR
KEGG bsu:BSU25290
NMPDR fig|224308.1.peg.2532
GenoList BSU25290
GeneTree EBGT00070000032135
HOGENOM HBG561652
OMA KVAKDWQ
PhylomeDB P42182
ProtClustDB PRK00089
BioCyc BSUB:BSU25290-MONOMER
GO GO:0005737
GO:0005886
GO:0005525
GO:0019843
GO:0042254
HAMAP MF_00367
InterPro IPR005662
IPR006073
IPR015946
IPR009019
IPR004044
IPR002917
IPR005225
Gene3D G3DSA:3.30.300.20
Pfam PF07650
PF01926
PRINTS PR00326
SUPFAM SSF54814
TIGRFAMs TIGR00436
TIGR00231
PROSITE PS50823

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded From UniProt

GO:0003723

RNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004044

F

Seeded From UniProt

GO:0003723

RNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005662

F

Seeded From UniProt

GO:0003723

RNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009019

F

Seeded From UniProt

GO:0003723

RNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0694

F

Seeded From UniProt

GO:0005525

GTP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002917

F

Seeded From UniProt

GO:0005525

GTP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005225

F

Seeded From UniProt

GO:0005525

GTP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005662

F

Seeded From UniProt

GO:0005525

GTP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006073

F

Seeded From UniProt

GO:0005525

GTP binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0342

F

Seeded From UniProt

GO:0005622

intracellular

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002917

C

Seeded From UniProt

GO:0005622

intracellular

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005662

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded From UniProt

GO:0005886

plasma membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded From UniProt

GO:0005886

plasma membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0039

C

Seeded From UniProt

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded From UniProt

GO:0019843

rRNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0699

F

Seeded From UniProt

GO:0042254

ribosome biogenesis

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0690

P

Seeded From UniProt

GO:0051781

positive regulation of cell division

PMID:12399511[1]

IMP: Inferred from Mutant Phenotype

P

Figure 2A is a micrograph image showing normal B. subtilis strain BR151. The cells are short with condensed nucleoids. Figure 2B is a micrograph image showing a Bex null mutant SL7968. The cells are elongated chains with diffuse nucleoids. This is implicates that Bex has a positive role in cell division, more specifically, cell cycle cytokinesis.

complete

GO:0032297

negative regulation of DNA-dependent DNA replication initiation

PMID:12427945[2]

IDA: Inferred from Direct Assay

P

Figure 6B shows that the absence of Bex shifts the number of replication origins from 2-4 to 4+ in presence of IPTG. This is evidence that the absence of Bex increases initiation of chromosome replication.

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Minkovsky N et al. (2002) Bex, the Bacillus subtilis homolog of the essential Escherichia coli GTPase Era, is required for normal cell division and spore formation. J Bacteriol 184: 6389-94 PubMed GONUTS page
  2. Morimoto T et al. (2002) Six GTP-binding proteins of the Era/Obg family are essential for cell growth in Bacillus subtilis. Microbiology 148: 3539-52 PubMed GONUTS page
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