ARATH:SRK2E

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Species (Taxon ID)	Arabidopsis thaliana (Mouse-ear cress). (taxon:3702)
Gene Name(s)	SRK2E ( synonyms: OST1, SNRK2.6 )
Protein Name(s)	Serine/threonine-protein kinase SRK2E Protein OPEN STOMATA 1 SNF1-related kinase 2.6 SnRK2.6 Serine/threonine-protein kinase OST1
External Links
UniProt Identifier	SRK2E_ARATH
UniProt Accessions	Q940H6, O81763,
EMBL	AJ316009, AL031032, AL161584, CP002687, AY054624, AY081538,
PIR	T05223,
RefSeq	NP_567945.1,
IntAct	Q940H6,
Pfam	PF00069,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005829	cytosol		IDA: Inferred from Direct Assay		C	Source: TAIR
	GO:0005634	nucleus		IDA: Inferred from Direct Assay		C	Source: TAIR
	GO:0005524	ATP binding		IEA: Inferred from Electronic Annotation		F	Source: UniProtKB-KW
	GO:0005515	protein binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0004674	protein serine/threonine kinase activity		IEA: Inferred from Electronic Annotation		F	Source: UniProtKB-KW
	GO:0009738	abscisic acid mediated signaling pathway		TAS: Traceable Author Statement		P	Source: TAIR
	GO:0042742	defense response to bacterium		IMP: Inferred from Mutant Phenotype		P	Source: TAIR
	GO:0040007	growth		IMP: Inferred from Mutant Phenotype		P	Source: TAIR
	GO:0048366	leaf development		IMP: Inferred from Mutant Phenotype		P	Source: TAIR
	GO:0006468	protein amino acid phosphorylation		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0080010	regulation of oxygen and reactive oxygen sp...		IMP: Inferred from Mutant Phenotype		P	Source: TAIR
	GO:0010119	regulation of stomatal movement		IMP: Inferred from Mutant Phenotype		P	Source: TAIR
	GO:0009651	response to salt stress		IDA: Inferred from Direct Assay		P	Source: TAIR
	GO:0009414	response to water deprivation		IMP: Inferred from Mutant Phenotype		P	Source: TAIR
	GO:0010118	stomatal movement		IMP: Inferred from Mutant Phenotype		P	Source: TAIR
	GO:0005985	sucrose metabolic process		IMP: Inferred from Mutant Phenotype		P	Source: TAIR
	GO:0019432	triglyceride biosynthetic process		IMP: Inferred from Mutant Phenotype		P	Source: TAIR
	GO:0006636	unsaturated fatty acid biosynthetic process		IMP: Inferred from Mutant Phenotype		P	Source: TAIR
incorrect (CACAO)	GO:0009737	response to abscisic acid stimulus	PMID:18442365^[1]	TAS: Traceable Author Statement		P	Disc. Pg.8 .... SnRK2.6 affects ABA-induced stomatal closure	complete
incorrect (CACAO)	GO:0010118	stomatal movement	PMID:18442365^[1]	TAS: Traceable Author Statement		P	Disc. Pg.8 .... SnRK2.6 affects ABA-induced stomatal closure	complete
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0004672	protein kinase activity	PMID:12468729^[2]	IDA: Inferred from Direct Assay		F
	GO:0004672	protein kinase activity	PMID:12514244^[3]	TAS: Traceable Author Statement		F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0723	F
	GO:0005515	protein binding	PMID:16365038^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P49597	F
	GO:0005515	protein binding	PMID:16365038^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P49597	F
	GO:0005515	protein binding	PMID:19874541^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P49597	F
	GO:0005515	protein binding	PMID:19874541^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P49597	F
	GO:0005515	protein binding	PMID:19955427^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q9LD83	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005634	nucleus	PMID:19880399^[7]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:19880399^[7]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	PMID:18433157^[8]	IDA: Inferred from Direct Assay		C
	GO:0005985	sucrose metabolic process	PMID:20200070^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	P
	GO:0006468	protein phosphorylation	PMID:12468729^[2]	IDA: Inferred from Direct Assay		P
	GO:0006468	protein phosphorylation	PMID:12514244^[3]	TAS: Traceable Author Statement		P
	GO:0006636	unsaturated fatty acid biosynthetic process	PMID:20200070^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0006952	defense response	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0611	P
	GO:0006970	response to osmotic stress	PMID:15292193^[10]	IDA: Inferred from Direct Assay		P
	GO:0009414	response to water deprivation	PMID:12047634^[11]	IMP: Inferred from Mutant Phenotype		P
	GO:0009414	response to water deprivation	PMID:12514244^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0009414	response to water deprivation	PMID:16682349^[12]	IMP: Inferred from Mutant Phenotype		P
	GO:0009651	response to salt stress	PMID:15292193^[10]	IDA: Inferred from Direct Assay		P
	GO:0009737	response to abscisic acid stimulus	PMID:12047634^[11]	IMP: Inferred from Mutant Phenotype		P
	GO:0009737	response to abscisic acid stimulus	PMID:12514244^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0009737	response to abscisic acid stimulus	PMID:15064385^[13]	IMP: Inferred from Mutant Phenotype		P
	GO:0009737	response to abscisic acid stimulus	PMID:15292193^[10]	IDA: Inferred from Direct Assay		P
	GO:0009737	response to abscisic acid stimulus	PMID:20200070^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0009737	response to abscisic acid stimulus	PMID:20733066^[14]	IDA: Inferred from Direct Assay		P
	GO:0009738	abscisic acid mediated signaling pathway	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0938	P
	GO:0009738	abscisic acid mediated signaling pathway	PMID:12514244^[3]	TAS: Traceable Author Statement		P
	GO:0010118	stomatal movement	PMID:16959575^[15]	IMP: Inferred from Mutant Phenotype		P
	GO:0010119	regulation of stomatal movement	PMID:12047634^[11]	IMP: Inferred from Mutant Phenotype		P
	GO:0010119	regulation of stomatal movement	PMID:12514244^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0010119	regulation of stomatal movement	PMID:15064385^[13]	IMP: Inferred from Mutant Phenotype		P
	GO:0010359	regulation of anion channel activity	PMID:19955427^[6]	IDA: Inferred from Direct Assay		P
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F
	GO:0016301	kinase activity	PMID:15292193^[10]	IDA: Inferred from Direct Assay		F
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P
	GO:0016310	phosphorylation	PMID:15292193^[10]	IDA: Inferred from Direct Assay		P
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F
	GO:0019432	triglyceride biosynthetic process	PMID:20200070^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0019903	protein phosphatase binding	PMID:19955427^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P49598	F
	GO:0040007	growth	PMID:20200070^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0042742	defense response to bacterium	PMID:16959575^[15]	IMP: Inferred from Mutant Phenotype		P
	GO:0048366	leaf development	PMID:20200070^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:2000377	regulation of reactive oxygen species metabolic process	PMID:15064385^[13]	IMP: Inferred from Mutant Phenotype		P
NOT	GO:0005829	cytosol	PMID:21166475^[16]	RCA: Inferred from Reviewed Computational Analysis		C
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Diédhiou CJ et al. (2008) The SNF1-type serine-threonine protein kinase SAPK4 regulates stress-responsive gene expression in rice. BMC Plant Biol 8: 49 PubMed GONUTS page
↑ ^2.0 ^2.1 Mustilli AC et al. (2002) Arabidopsis OST1 protein kinase mediates the regulation of stomatal aperture by abscisic acid and acts upstream of reactive oxygen species production. Plant Cell 14: 3089-99 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Yoshida R et al. (2002) ABA-activated SnRK2 protein kinase is required for dehydration stress signaling in Arabidopsis. Plant Cell Physiol 43: 1473-83 PubMed GONUTS page
↑ ^4.0 ^4.1 Yoshida R et al. (2006) The regulatory domain of SRK2E/OST1/SnRK2.6 interacts with ABI1 and integrates abscisic acid (ABA) and osmotic stress signals controlling stomatal closure in Arabidopsis. J Biol Chem 281: 5310-8 PubMed GONUTS page
↑ ^5.0 ^5.1 Nishimura N et al. (2010) PYR/PYL/RCAR family members are major in-vivo ABI1 protein phosphatase 2C-interacting proteins in Arabidopsis. Plant J 61: 290-9 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Lee SC et al. (2009) A protein kinase-phosphatase pair interacts with an ion channel to regulate ABA signaling in plant guard cells. Proc Natl Acad Sci U S A 106: 21419-24 PubMed GONUTS page
↑ ^7.0 ^7.1 Fujita Y et al. (2009) Three SnRK2 protein kinases are the main positive regulators of abscisic acid signaling in response to water stress in Arabidopsis. Plant Cell Physiol 50: 2123-32 PubMed GONUTS page
↑ de la Fuente van Bentem S et al. (2008) Site-specific phosphorylation profiling of Arabidopsis proteins by mass spectrometry and peptide chip analysis. J Proteome Res 7: 2458-70 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Zheng Z et al. (2010) The protein kinase SnRK2.6 mediates the regulation of sucrose metabolism and plant growth in Arabidopsis. Plant Physiol 153: 99-113 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Boudsocq M et al. (2004) Identification of nine sucrose nonfermenting 1-related protein kinases 2 activated by hyperosmotic and saline stresses in Arabidopsis thaliana. J Biol Chem 279: 41758-66 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Merlot S et al. (2002) Use of infrared thermal imaging to isolate Arabidopsis mutants defective in stomatal regulation. Plant J 30: 601-9 PubMed GONUTS page
↑ Xie X et al. (2006) The identification of genes involved in the stomatal response to reduced atmospheric relative humidity. Curr Biol 16: 882-7 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Suhita D et al. (2004) Cytoplasmic alkalization precedes reactive oxygen species production during methyl jasmonate- and abscisic acid-induced stomatal closure. Plant Physiol 134: 1536-45 PubMed GONUTS page
↑ Kline KG et al. (2010) In planta changes in protein phosphorylation induced by the plant hormone abscisic acid. Proc Natl Acad Sci U S A 107: 15986-91 PubMed GONUTS page
↑ ^15.0 ^15.1 Melotto M et al. (2006) Plant stomata function in innate immunity against bacterial invasion. Cell 126: 969-80 PubMed GONUTS page
↑ Ito J et al. (2011) Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. J Proteome Res 10: 1571-82 PubMed GONUTS page

[PMID:18442365-0] 1.0 ^1.1 Diédhiou CJ et al. (2008) The SNF1-type serine-threonine protein kinase SAPK4 regulates stress-responsive gene expression in rice. BMC Plant Biol 8: 49 PubMed GONUTS page

[PMID:12468729-1] 2.0 ^2.1 Mustilli AC et al. (2002) Arabidopsis OST1 protein kinase mediates the regulation of stomatal aperture by abscisic acid and acts upstream of reactive oxygen species production. Plant Cell 14: 3089-99 PubMed GONUTS page

[PMID:12514244-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Yoshida R et al. (2002) ABA-activated SnRK2 protein kinase is required for dehydration stress signaling in Arabidopsis. Plant Cell Physiol 43: 1473-83 PubMed GONUTS page

[PMID:16365038-3] 4.0 ^4.1 Yoshida R et al. (2006) The regulatory domain of SRK2E/OST1/SnRK2.6 interacts with ABI1 and integrates abscisic acid (ABA) and osmotic stress signals controlling stomatal closure in Arabidopsis. J Biol Chem 281: 5310-8 PubMed GONUTS page

[PMID:19874541-4] 5.0 ^5.1 Nishimura N et al. (2010) PYR/PYL/RCAR family members are major in-vivo ABI1 protein phosphatase 2C-interacting proteins in Arabidopsis. Plant J 61: 290-9 PubMed GONUTS page

[PMID:19955427-5] 6.0 ^6.1 ^6.2 Lee SC et al. (2009) A protein kinase-phosphatase pair interacts with an ion channel to regulate ABA signaling in plant guard cells. Proc Natl Acad Sci U S A 106: 21419-24 PubMed GONUTS page

[PMID:19880399-6] 7.0 ^7.1 Fujita Y et al. (2009) Three SnRK2 protein kinases are the main positive regulators of abscisic acid signaling in response to water stress in Arabidopsis. Plant Cell Physiol 50: 2123-32 PubMed GONUTS page

[PMID:18433157-7] Fuente van Bentem S et al. (2008) Site-specific phosphorylation profiling of Arabidopsis proteins by mass spectrometry and peptide chip analysis. J Proteome Res 7: 2458-70 PubMed GONUTS page

[PMID:20200070-8] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Zheng Z et al. (2010) The protein kinase SnRK2.6 mediates the regulation of sucrose metabolism and plant growth in Arabidopsis. Plant Physiol 153: 99-113 PubMed GONUTS page

[PMID:15292193-9] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Boudsocq M et al. (2004) Identification of nine sucrose nonfermenting 1-related protein kinases 2 activated by hyperosmotic and saline stresses in Arabidopsis thaliana. J Biol Chem 279: 41758-66 PubMed GONUTS page

[PMID:12047634-10] 11.0 ^11.1 ^11.2 Merlot S et al. (2002) Use of infrared thermal imaging to isolate Arabidopsis mutants defective in stomatal regulation. Plant J 30: 601-9 PubMed GONUTS page

[PMID:16682349-11] Xie X et al. (2006) The identification of genes involved in the stomatal response to reduced atmospheric relative humidity. Curr Biol 16: 882-7 PubMed GONUTS page

[PMID:15064385-12] 13.0 ^13.1 ^13.2 Suhita D et al. (2004) Cytoplasmic alkalization precedes reactive oxygen species production during methyl jasmonate- and abscisic acid-induced stomatal closure. Plant Physiol 134: 1536-45 PubMed GONUTS page

[PMID:20733066-13] Kline KG et al. (2010) In planta changes in protein phosphorylation induced by the plant hormone abscisic acid. Proc Natl Acad Sci U S A 107: 15986-91 PubMed GONUTS page

[PMID:16959575-14] 15.0 ^15.1 Melotto M et al. (2006) Plant stomata function in innate immunity against bacterial invasion. Cell 126: 969-80 PubMed GONUTS page

[PMID:21166475-15] Ito J et al. (2011) Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. J Proteome Res 10: 1571-82 PubMed GONUTS page

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ARATH:SRK2E

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