ARATH:RAR1

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Species (Taxon ID)	Arabidopsis thaliana (Mouse-ear cress). (taxon:3702)
Gene Name(s)	RAR1 ( synonyms: PBS2, RPR2 )
Protein Name(s)	Cysteine and histidine-rich domain-containing protein RAR1 AtRAR1 CHORD domain-containing protein RAR1 Protein PPHB SUSCEPTIBLE 2 Protein REQUIRED FOR MLA12 RESISTANCE 1
External Links
UniProt Identifier	RAR1_ARATH
UniProt Accessions	Q9SE33, Q9FLI9,
EMBL	AF192262, AB010074, CP002688, AY088919,
RefSeq	NP_568762.6,
PDB	2XCM,
IntAct	Q9SE33,
Pfam	PF04968,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0042742	defense response to bacterium	PMID:10224270^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0042742	defense response to bacterium	PMID:17148606^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0042742	defense response to bacterium	PMID:17279625^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0008270	zinc ion binding	PMID:17279625^[3]	IDA: Inferred from Direct Assay		F
	GO:0009816	defense response to bacterium, incompatible interaction	PMID:12034893^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0009817	defense response to fungus, incompatible interaction	PMID:12034891^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0009626	plant-type hypersensitive response	PMID:12034893^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0009816	defense response to bacterium, incompatible interaction	PMID:12034891^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0005515	protein binding	PMID:11847307^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q9SUR9	F
	GO:0051879	Hsp90 protein binding	PMID:14592967^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P55737	F
	GO:0009626	plant-type hypersensitive response	PMID:12034891^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0005515	protein binding	PMID:17148606^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9SUT5	F
	GO:0002679	respiratory burst involved in defense response	PMID:12034891^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0002679	respiratory burst involved in defense response	PMID:12034893^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0005515	protein binding	PMID:11847307^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q9SUT5	F
	GO:0050821	protein stabilization	PMID:15976272^[8]	IMP: Inferred from Mutant Phenotype		P
	GO:0045087	innate immune response	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0399	P
	GO:0005515	protein binding	PMID:14504384^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P27323	F
	GO:0005515	protein binding	PMID:19487680^[10]	IPI: Inferred from Physical Interaction	UniProtKB:P55737	F
	GO:0009817	defense response to fungus, incompatible interaction	PMID:10224270^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0009817	defense response to fungus, incompatible interaction	PMID:12034893^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0006952	defense response	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0611	P
	GO:0008270	zinc ion binding	PMID:17279625^[3]	IDA: Inferred from Direct Assay		F
	GO:0005515	protein binding	PMID:17148606^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P27323	F
	GO:0005515	protein binding	PMID:11847307^[6]	IPI: Inferred from Physical Interaction		F
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0002679	respiratory burst involved in defense response	PMID:12034891^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0002679	respiratory burst involved in defense response	PMID:12034891^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0002679	respiratory burst involved in defense response	PMID:12034893^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0002679	respiratory burst involved in defense response	PMID:12034893^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0005515	protein binding	PMID:11847307^[6]	IPI: Inferred from Physical Interaction	TAIR:gene:3353745	F
	GO:0005515	protein binding	PMID:11847307^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q9SUR9	F
	GO:0005515	protein binding	PMID:11847307^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q9SUR9	F
	GO:0005515	protein binding	PMID:11847307^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q9SUT5	F
	GO:0005515	protein binding	PMID:11847307^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q9SUT5	F
	GO:0005515	protein binding	PMID:14504384^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P27323	F
	GO:0005515	protein binding	PMID:14504384^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P27323	F
	GO:0005515	protein binding	PMID:17148606^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P27323	F
	GO:0005515	protein binding	PMID:17148606^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P27323	F
	GO:0005515	protein binding	PMID:17148606^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9SUT5	F
	GO:0005515	protein binding	PMID:17148606^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9SUT5	F
	GO:0005515	protein binding	PMID:19487680^[10]	IPI: Inferred from Physical Interaction	UniProtKB:P55737	F
	GO:0005515	protein binding	PMID:19487680^[10]	IPI: Inferred from Physical Interaction	UniProtKB:P55737	F
	GO:0005575	cellular component	GO_REF:0000015	ND: No biological Data available		C
	GO:0006952	defense response	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0611	P
	GO:0008270	zinc ion binding	PMID:17279625^[3]	IDA: Inferred from Direct Assay		F
	GO:0008270	zinc ion binding	PMID:17279625^[3]	IDA: Inferred from Direct Assay		F
	GO:0009626	plant-type hypersensitive response	PMID:12034891^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0009626	plant-type hypersensitive response	PMID:12034891^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0009626	plant-type hypersensitive response	PMID:12034893^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0009626	plant-type hypersensitive response	PMID:12034893^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0009816	defense response to bacterium, incompatible interaction	PMID:12034891^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0009816	defense response to bacterium, incompatible interaction	PMID:12034891^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0009816	defense response to bacterium, incompatible interaction	PMID:12034893^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0009816	defense response to bacterium, incompatible interaction	PMID:12034893^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0009817	defense response to fungus, incompatible interaction	PMID:10224270^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0009817	defense response to fungus, incompatible interaction	PMID:12034891^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0009817	defense response to fungus, incompatible interaction	PMID:12034891^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0009817	defense response to fungus, incompatible interaction	PMID:12034893^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0009817	defense response to fungus, incompatible interaction	PMID:12034893^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0042742	defense response to bacterium	PMID:10224270^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0042742	defense response to bacterium	PMID:17148606^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0042742	defense response to bacterium	PMID:17148606^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0042742	defense response to bacterium	PMID:17279625^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0042742	defense response to bacterium	PMID:17279625^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0045087	innate immune response	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0399	P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0050821	protein stabilization	PMID:15976272^[8]	IMP: Inferred from Mutant Phenotype		P
	GO:0051879	Hsp90 protein binding	PMID:14592967^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P55737	F
	GO:0051879	Hsp90 protein binding	PMID:14592967^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P55737	F
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Warren RF et al. (1999) Identification of three putative signal transduction genes involved in R gene-specified disease resistance in Arabidopsis. Genetics 152: 401-12 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Shang Y et al. (2006) RAR1, a central player in plant immunity, is targeted by Pseudomonas syringae effector AvrB. Proc Natl Acad Sci U S A 103: 19200-5 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Heise CT et al. (2007) Biochemical characterization of RAR1 cysteine- and histidine-rich domains (CHORDs): a novel class of zinc-dependent protein-protein interaction modules. Biochemistry 46: 1612-23 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 Tornero P et al. (2002) RAR1 and NDR1 contribute quantitatively to disease resistance in Arabidopsis, and their relative contributions are dependent on the R gene assayed. Plant Cell 14: 1005-15 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 Muskett PR et al. (2002) Arabidopsis RAR1 exerts rate-limiting control of R gene-mediated defenses against multiple pathogens. Plant Cell 14: 979-92 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Azevedo C et al. (2002) The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance. Science 295: 2073-6 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Hubert DA et al. (2003) Cytosolic HSP90 associates with and modulates the Arabidopsis RPM1 disease resistance protein. EMBO J 22: 5679-89 PubMed GONUTS page
↑ ^8.0 ^8.1 Holt BF 3rd et al. (2005) Antagonistic control of disease resistance protein stability in the plant immune system. Science 309: 929-32 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Takahashi A et al. (2003) HSP90 interacts with RAR1 and SGT1 and is essential for RPS2-mediated disease resistance in Arabidopsis. Proc Natl Acad Sci U S A 100: 11777-82 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Hubert DA et al. (2009) Specific Arabidopsis HSP90.2 alleles recapitulate RAR1 cochaperone function in plant NB-LRR disease resistance protein regulation. Proc Natl Acad Sci U S A 106: 9556-63 PubMed GONUTS page

[PMID:10224270-0] 1.0 ^1.1 ^1.2 ^1.3 Warren RF et al. (1999) Identification of three putative signal transduction genes involved in R gene-specified disease resistance in Arabidopsis. Genetics 152: 401-12 PubMed GONUTS page

[PMID:17148606-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Shang Y et al. (2006) RAR1, a central player in plant immunity, is targeted by Pseudomonas syringae effector AvrB. Proc Natl Acad Sci U S A 103: 19200-5 PubMed GONUTS page

[PMID:17279625-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Heise CT et al. (2007) Biochemical characterization of RAR1 cysteine- and histidine-rich domains (CHORDs): a novel class of zinc-dependent protein-protein interaction modules. Biochemistry 46: 1612-23 PubMed GONUTS page

[PMID:12034893-3] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 Tornero P et al. (2002) RAR1 and NDR1 contribute quantitatively to disease resistance in Arabidopsis, and their relative contributions are dependent on the R gene assayed. Plant Cell 14: 1005-15 PubMed GONUTS page

[PMID:12034891-4] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 Muskett PR et al. (2002) Arabidopsis RAR1 exerts rate-limiting control of R gene-mediated defenses against multiple pathogens. Plant Cell 14: 979-92 PubMed GONUTS page

[PMID:11847307-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Azevedo C et al. (2002) The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance. Science 295: 2073-6 PubMed GONUTS page

[PMID:14592967-6] 7.0 ^7.1 ^7.2 Hubert DA et al. (2003) Cytosolic HSP90 associates with and modulates the Arabidopsis RPM1 disease resistance protein. EMBO J 22: 5679-89 PubMed GONUTS page

[PMID:15976272-7] 8.0 ^8.1 Holt BF 3rd et al. (2005) Antagonistic control of disease resistance protein stability in the plant immune system. Science 309: 929-32 PubMed GONUTS page

[PMID:14504384-8] 9.0 ^9.1 ^9.2 Takahashi A et al. (2003) HSP90 interacts with RAR1 and SGT1 and is essential for RPS2-mediated disease resistance in Arabidopsis. Proc Natl Acad Sci U S A 100: 11777-82 PubMed GONUTS page

[PMID:19487680-9] 10.0 ^10.1 ^10.2 Hubert DA et al. (2009) Specific Arabidopsis HSP90.2 alleles recapitulate RAR1 cochaperone function in plant NB-LRR disease resistance protein regulation. Proc Natl Acad Sci U S A 106: 9556-63 PubMed GONUTS page

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ARATH:RAR1

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